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Abstract

Pelletization process first came into existence way back during the 1950s, when the first product was introduced to the market. These pelletized dosage forms have gained popularity considerably from then because of their distinct advantages, such as ease of capsule filling because of better flow properties of the perfectly spherical pellets; enhancement of drug dissolution; ease of coating; sustained, controlled, or site-specific delivery of the drug from coated pellets; uniform packing; even distribution in the GI tract; and less GI irritation. Pelletized dosage forms can be prepared by a number of techniques, including drug layering on nonpareil sugar or microcrystalline cellulose beads, spray drying, spray congealing, roto granulation, hot-melt extrusion, and spheronization of low melting materials or extrusion-spheronization of a wet mass. The present review outlines the recent findings on the manufacturing and evaluation of spherical pellets. The techniques namely extrusion-spheronization, hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with formulation requirements for the process, parameters affecting pelletization. Evaluation of quality of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength.

The Art of Positronics in Contemporary Nanomaterials Science: A Case Study of Sub-Nanometer Scaled Glassy Arsenoselenides

“…The most effective positron trapping centers of this type are multiatomic vacancies stabilized in the g-As-Se network at the bottom of AsSe 3/2 pyramids in a preferentially negative environment of chalcogen (Se) atoms [ 48 , 49 , 50 , 51 , 52 , 53 ]. Another group of positron traps (denoted in Table 4 as {e + } g-As-Se –IF-1,2,3) is character to fgp g-As-Se, these FVE being stabilized under pelletization [ 61 ] as GB and TJ (i.e., intersection between three or more adjoining NP) in samples of different milling, pre-history [ 62 , 63 , 64 , 65 , 66 ].…”

“…These FVE represent IF free-volume spaces between contacting NP (such as disclinations or TJ between adjoining NP), where both conditions stabilizing Ps-related states [ 24 , 32 ] are satisfied. For metallic multi-particulate systems, the most essential excess of additional free volume is expected with individual crystallites less than 5–10 nm [ 62 , 63 , 64 , 65 ].…”

İzosorbi̇d Di̇ni̇tratin Modi̇fi̇ye Salim Yapan Çok Bi̇ri̇mli̇ Bi̇leşi̇mi̇ni̇n Tablet Şekli̇nde Basilmasi Ve Değerlendi̇ri̇lmesi̇

“…In turn, today multicomponent dosage forms are increasingly used in comparison with monolithic medicinal forms. They have a number of potential benefits, such as predicted gastrointestinal movement, overdose risk absence, ability to manage the release profile, increased bioavailability, and also less intra-subject and inter-subject variability in pharmacokinetic characteristics [7][8][9]. The drugs requiring long-term therapeutic effect for the treatment of such cardiovascular diseases, in particular such as arterial hypertension and angina pectoris, are suitable for the development of sustained release multi-dose formulations [10,11].…”

Backfill of Radioactive Waste Disposal: Feasibility Study of Argillite/Bentonite (COx/MX80) Pellets

“…Different manufacturing procedures lead to different pelletizing techniques. According to [33,34] the main pelletizing methods are agitation (balling process), compaction (compression or extrusion), layering, and globulation. In soil materials, compaction has been the main pelletization technique.…”