639 Cytokeratin 18 as a Potential Marker Predicts Early Local Recurrence of Hepatocellular Carcinoma After Curative Local Ablation

Elalfy, Hatem; Basheer, T.; El-Hussiny, Mona Abo-Bakr; Alsayed, Sahar Alsayed Mohamed; Alhaware, G.

doi:10.1016/s0168-8278(13)60641-8

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“…With the development of immunology and molecular biology, the studies in tumor markers have been increasing in order to provide accurate diagnosis, treatment and prognosis ( 6 , 8 – 10 ). Cytokeratin is an important tumor marker of epithelium origin, it had been investigated in the studies of many epithelium derived malignant tumors ( 11 , 12 ). Cytokeratin is extensively distributed in epithelium and an intermediate filament in the dynamic network structure of cytoskeleton.…”

Section: Discussionmentioning

confidence: 99%

“…Mandibular gingival squamous cell carcinoma were confirmed for all patients by histopathological examination after surgery. Forty-two patients were staged according to the International Union against Cancer (UICC) Criteria 2002, i.e., T1 stage ( 9 ), T2 ( 16 ), T3 ( 6 ) and T4 ( 11 ). Cervical lymph nodes were collected following Haagensen's method, then were numbered and sent for pathological examination.…”

Section: Methodsmentioning

confidence: 99%

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Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma

Duan

Xu²,

Zhang

et al. 2018

Oncol Lett

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The present study aims to analyze the expression of broad spectrum cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma and explore the metastasis of mandibular gingival squamous cell carcinoma in cervical lymph nodes. This study included 42 patients with mandibular gingival squamous cell carcinoma, which was staged according to the clinical staging criteria by International Union Against Cancer 2002 (UICC) and the Level staging method of cervical lymph node by American Academy of Otolaryngology-Head and Neck Surgery 1991. Monoclonal mouse anti-human cytokeratin (AE1/AE3) antibody was used in immunohistochemical examination and hematoxylin and eosin (H&E) staining. All positive sections by H&E staining were also positive by immunohistochemistry (IHC). The positive rate of routine H&E staining and serial-section H&E staining was 8.03 and 9.57%, respectively, the positive rate of IHC was 12.82%. The positive rate of IHC was significantly different with that of routine H&E staining (χ2=7.17, P<0.01), yet not significantly different with that of serial-section H&E staining (χ2=3.10, P>0.05). Lymph node metastasis was mainly in Level I, II and III, both serial-section H&E staining and IHC showed lymph node metastasis in Level IV for advanced patients. IHC showed 19 lymph node micrometastasis in 12 patients, while neither serial-section nor routine H&E staining showed micrometastasis. Lymph node dissection of hyoid bone (mainly in Level I, II and III) could be used for early patients, and the dissection could be expanded to Level IV for advanced patients.

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