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Copper-Catalyzed Construction of Benzo[4,5]imidazo[2,1-a]isoquinolines Using Calcium Carbide as a Solid Alkyne Source

“…Benzimidazoles and isoquinolines as important nitrogen-containing heterocycles are constituents of many bioactive compounds that are of wide interest because of their diverse biological and clinical applications. Therefore, compounds including both benzimidazole and isoquinoline moieties in one molecule are potential sources of leads for drug discovery .…”

Synthesis and antibacterial activity of new spiro-isoquinolin-1-ones

“…4-Spiro-isoquinolinones derivatives are attractive compounds of growing pharmaceutical interest. [1][2][3] These compounds have been synthesised by using various methods [4][5][6][7] essentially involving 1,3-dipolar cycloaddition reactions to the exocylic C-C bond of specific isoquinoline-4-ylidene derivatives. This method has proved to be an excellent synthetic route although there are few examples of such systems reported in the literature.…”

Stereoselective Synthesis of Hexahydro-1H-spiro[isoquinoline-4,4′-pyran] Scaffolds through an Intramolecular Prins Cascade Process

“…The above properties make them attractive synthetic targets . In particular, the spiroisoquinoline and its derivatives are known to exhibit a broad spectrum of biological activities such as antiarrhythmic, antidepressant, stimulant effect on respiration, analgesic, and cardiotonic behavior (Figure ) …”