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Sinha, Arvind; Das, Swapan Kumar; Kumar, T Vijaya; Rao, V. Venkateswara; Ramachandrarao, P.

doi:10.1023/a:1021818014207

Cited by 30 publications

(21 citation statements)

References 2 publications

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“…The reduction of Cu 2 + salts using borohydride is a complex process, and the resulting product is affected by various experimental conditions including concentration reactants, solvent, temperature and the presence of chelating groups. [ 32 ] Sinha et al [ 33 ] describe a simple and effi cient production of nanosized Cu ° particulate using borohydride reduction, but note that oxidation is facile upon introduction of air. This latter observation is consistent with the known instability of metallic copper surfaces in the nanosize regime, [ 34 ] which has been reported to result in copper/copper oxide core-shell species (e.g., Cu/ CuO or Cu 2 O).…”

Section: Fabrication Of Antimicrobial Nanoparticle Coatings On Naturamentioning

confidence: 99%

Copper‐Based Nanostructured Coatings on Natural Cellulose: Nanocomposites Exhibiting Rapid and Efficient Inhibition of a Multi‐Drug Resistant Wound Pathogen, A. baumannii, and Mammalian Cell Biocompatibility In Vitro

Cady¹,

Behnke²,

Strickland³

2011

Adv Funct Materials

196

124

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This paper describes a layer‐by‐layer (LBL) electrostatic self‐assembly process for fabricating highly efficient antimicrobial nanocoatings on a natural cellulose substrate. The composite materials comprise a chemically modified cotton substrate and a layer of sub‐5 nm copper‐based nanoparticles. The LBL process involves a chemical preconditioning step to impart high negative surface charge on the cotton substrate for chelation controlled binding of cupric ions (Cu2+), followed by chemical reduction to yield nanostructured coatings on cotton fibers. These model wound dressings exhibit rapid and efficient killing of a multidrug resistant bacterial wound pathogen, A. baumannii, where an 8‐log reduction in bacterial growth can be achieved in as little as 10 min of contact. Comparative silver‐based nanocoated wound dressings–a more conventional antimicrobial composite material–exhibit much lower antimicrobial efficiencies; a 5‐log reduction in A. baumannii growth is possible after 24 h exposure times to silver nanoparticle‐coated cotton substrates. The copper nanoparticle–cotton composites described herein also resist leaching of copper species in the presence of buffer, and exhibit an order of magnitude higher killing efficiency using 20 times less total metal when compared to tests using soluble Cu2+. Together these data suggest that copper‐based nanoparticle‐coated cotton materials have facile antimicrobial properties in the presence of A. baumannii through a process that may be associated with contact killing, and not simply due to enhanced release of metal ion. The biocompatibility of these copper‐cotton composites toward embryonic fibroblast stem cells in vitro suggests their potential as a new paradigm in metal‐based wound care and combating pathogenic bacterial infections.

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Section: Fabrication Of Antimicrobial Nanoparticle Coatings On Naturamentioning

confidence: 99%

Copper‐Based Nanostructured Coatings on Natural Cellulose: Nanocomposites Exhibiting Rapid and Efficient Inhibition of a Multi‐Drug Resistant Wound Pathogen, A. baumannii, and Mammalian Cell Biocompatibility In Vitro

Cady¹,

Behnke²,

Strickland³

2011

Adv Funct Materials

196

124

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“…[24][25][26]27]. The general procedure used for the synthesis of polymer-metal composites is described below.…”

Section: Methodsmentioning

confidence: 99%

Morphological and Mechanical Properties of Poly (Vinyl Alcohol) Doped with Inorganic Fillers

Singh

Kulkarni

2013

International Journal of Polymeric Materials and Polymeric Biom

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A number of polymer composite films using polyvinyl alcohol (PVA) as the preorganized polymer matrix were synthesized embedding different metal salts of transition elements like copper, cobalt, nickel, iron, cadmium, and zinc by a biomimetic route. The metal salts present in composites were reduced in situ to metallic form. The composites were characterized by FTIR, SEM, and EDAX. The SEM analysis confirmed the presence of nano-sized metal particles uniformly distributed in the polymer matrix. Mechanical properties were measured for various composite and PVA films. Significant improvement in some of the mechanical properties of polymer composites was realized in comparison with PVA.

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“…Generally, high pure, well crystalline, non-agglomerated, uniformshaped, nanometer-sized Cu powders with a narrow size distribution are highly desirable to serve this purpose [1]. Among the various methods developed for the preparation of Cu powders [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], chemical solution routes facilitate molecular/atomic level control and also efficient scale up for processing and production. The chemical solution routes essentially involve precipitation of metallic Cu through chemical reduction of a salt, oxide or hydroxide of copper in solution.…”

Section: Introductionmentioning

confidence: 99%

“…The chemical solution routes essentially involve precipitation of metallic Cu through chemical reduction of a salt, oxide or hydroxide of copper in solution. However, most of these synthetic methods reported to [1,[7][8][9] or use reducing agents such as hydrogen [10], hydrazine [11,12], sodium borohydride [13], phosphite [14], or hydroxylammine hydrochloride [15], etc. which are highly reactive chemicals and pose potential environmental and biological risks.…”

Section: Introductionmentioning

confidence: 99%