In this paper, the excitation function utilizing the nuclear reaction nat V(p,X) 44 Ti was determined. The seven investigated metallic vanadium disks were proton irradiated within an energy range of 111-954 MeV between 1995 to 1996. The experiments' cross sections were validated using two independent measurements by combining γ spectrometry with both a low-energy germanium detector and a high-purity germanium detector. The maximum cross section was observed for energies of 145 ± 1.2 and 150.2 ± 1.2 MeV with values of 803 ± 28 and 805 ± 27 μb, respectively. In this regard, it was demonstrated that our data were in good agreement with the former, however, unpublished results which were investigated over a similar energy range. Thus, combined with these earlier measurements, a consistent data set for the nat V(p,X) 44 Ti excitation function from 111 to 1350 MeV is provided. Model calculations using Liège Intranuclear Cascade (INCL)/ABLA reproduce the shape of the excitation function correctly but overpredict the absolute values by factors of 2 to 3. Some considerations regarding this already earlier observed systematic overestimation of neutron-poor residues are given. The results will trigger new approaches in code development in order to improve the predictions.