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Ковалев, И. Е.; Karganov, M. Yu.; Rumyantseva, E. I.; Kovaleva, O. I.

doi:10.1023/a:1020771930653

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…We also found a relationship of diabetes-dependent hypertriglyceridemia and hypercholesterolemia with an increased amount of 20-to 40-nm particles in the LC spectrum of blood serum [2].…”

supporting

confidence: 55%

“…Earlier, we performed pioneering studies on the efficiency of laser correlation spectroscopy (LCS) for detecting and analyzing macromolecular components of blood serum in insulin-dependent diabetes mellitus (IDDM) [1][2][3][4]. These studies demonstrated that IDDM was characterized by substantial changes in the histogram of macromolecular components of blood serum compared to the normal state.…”

mentioning

confidence: 99%

“…The DNA that is found in the blood serum interacted intensely with serum macromolecules, forming complexes with them in the range from 1000 to 10000 nm. In addition, a large proportion of complexes of 100-500 nm in radius was found in the LC spectra of the blood serum of IDDM patients with active autoimmune processes [2].…”

mentioning

confidence: 99%

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Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Rumyantseva

Ковалев

Kovaleva

et al. 2005

Dokl Biochem Biophys

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“…We also found a relationship of diabetes-dependent hypertriglyceridemia and hypercholesterolemia with an increased amount of 20-to 40-nm particles in the LC spectrum of blood serum [2].…”

supporting

confidence: 55%

mentioning

confidence: 99%

See 1 more Smart Citation

Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Rumyantseva

Ковалев

Kovaleva

et al. 2005

Dokl Biochem Biophys

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Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

et al. 2014

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The objective of this study was to compare informative value of traditional approach (anti-AChR antibody radioimmunoassay) and evaluation of metabolic shifts by laser correlation spectroscopy in myasthenia gravis. The method based on changes in spectral characteristics of laser radiation caused by scattering in a disperse system yields a histogram reflecting particle contribution into light scatter as a function of particle radius in nanometers. The spectrum of anti-AChR-positive serum is characterized by appreciably increased contribution of particles with a radius 4.6–6.2 nm. Binding of serum components with solubilized AChR confirms that this peak is determined by elevated concentration of antibodies to this receptor. The search for the relationship between the disease severity and the distribution pattern of subfraction serum components revealed three informative zones: 6–15, 27–67, and 127–223 nm. In patients without disturbances of vital functions, the contribution of the first zone particles into light scatter increases and that of the third zone particles decreases. Considerable differences attaining the level of statistical significance in zones 4–6 and 20 nm were revealed in the spectra of serum from patients with myasthenia gravis of the same severity with and without thymoma. This opens prospects for dynamic monitoring of the efficiency of therapy.

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The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals

Алчинова¹

2015

AJLS

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Exposure to ionizing radiation leads to exhaustion of the pool of stem cells, increases differentiated cell stress, and activated reparation and apoptosis processes. Apart from well-documented acute effects, radiotherapy leads to delayed effects manifesting in few years after successful treatment. The aim of our study was the development of a test battery for evaluation of irradiation aftereffects in organisms characterized by different radiosensitivity. We chose C57BL mice as the ideal strain, because according to published data, they are characterized by medium radiosensitivity. At the preliminary stage, we have to assess informative value of some methods for the sublethal irradiation dose of 750 R. For evaluation of the damaging effects of radiation (lymphocyte count and maturity), we used, along with classical criteria, some complex parameters (body weight, serum homeostasis, behavior) characterizing general status of the organism. We also performed histological analysis of the liver, spleen, and pancreas and ranged the injuries by their severity.

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Cited by 4 publications

References 1 publication

Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Laser Correlation Spectroscopy of Macromolecular Complexes in Blood Serum Is an Efficient Method for Detecting Insulin Overdose and Correction of the Insulin Therapy for Diabetes Mellitus in Children

Comparative Analysis of the Informative Value of Radioimmunoassay and Laser Correlation Spectroscopy in Myasthenia Gravis

The Complex of Tests for the Quantitative Evaluation of the Effects of Radiation on Laboratory Animals

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