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Caddock, B. D.; Hüll, D.

doi:10.1023/a:1013808402289

Cited by 26 publications

(13 citation statements)

References 6 publications

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“…Chemical composition of the solution determines its physical, chemical, and rheological properties, the diffusivity of the solvent (and the cosolutes) in the solution, crystallization rates of the cosolutes, and ultimately, the final thermodynamic state after drying. Hydrophilic surfaces induce contact line pinning for sessile droplets, causing ring-like deposits in the periphery (41,42). One of the main factors contributing to spatial heterogeneity in a drying sessile droplet is the variation of the solvent evaporation flux on the droplet surface.…”

Section: Desiccation Phenomenamentioning

confidence: 99%

Heterogeneity in Desiccated Solutions: Implications for Biostabilization

Ragoonanan

Aksan

2008

Biophysical Journal

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Biopreservation processes such as freezing and drying inherently introduce heterogeneity. We focused on exploring the mechanisms responsible for heterogeneity in isothermal, diffusively dried biopreservation solutions that contain a model protein. The biopreservation solutions used contained trehalose (a sugar known for its stabilization effect) and salts (LiCl, NaCl, MgCl2, and CaCl2). Performing Fourier transform infrared spectroscopy analysis on the desiccated droplets, spatial distributions of the components within the dried droplet, as well as their specific interactions, were investigated. It was established that the formation of multiple thermodynamic states was induced by the spatial variations in the cosolute concentration gradients, directly affecting the final structure of the preserved protein. The spatial distribution gradients were formed by two competing flows that formed within the drying droplet: a dominant peripheral flow, induced by contact line pinning, and the Marangoni flow, induced by surface tension gradients. It was found that the changes in cosolute concentrations and drying conditions affected the spatial heterogeneity and stability of the product. It was also found that trehalose and salts had a synergistic stabilizing effect on the protein structure, which originated from destructuring of the vicinal water, which in turn mediated the interactions of trehalose with the protein. This interaction was observed by the change in the glycosidic CO, and the CH stretch vibrations of the trehalose molecule.

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Section: Desiccation Phenomenamentioning

confidence: 99%

Heterogeneity in Desiccated Solutions: Implications for Biostabilization

Ragoonanan

Aksan

2008

Biophysical Journal

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“…Obtaining this control will aid in ensuring the resistance to failure while staying eco-friendly [3], especially for applications requiring thick and/or hard coatings. Amongst several other parameters (thickness [8], ionic strength [9], substrate adhesion [10]...), the drying rate significantly impacts the cracking patterns [11][12][13]. This observation remains poorly understood for several reasons.…”

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confidence: 99%

Role of evaporation rate on the particle organization and crack patterns obtained by drying a colloidal layer

Piroird¹,

Lazarus²,

Gauthier³

et al. 2016

EPL

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A scientific hurdle in manufacturing solid films by drying colloidal layers is preventing them from fracturing. This paper examines how the drying rate of colloidal liquids influences the particle packing at the nanoscale in correlation with the crack patterns observed at the macroscale. Increasing the drying rate results in more ordered, denser solid structures, and the dried samples have more cracks.Yet, introducing a holding period (at a prescribed point) during the drying protocol results in a more disordered solid structure with significantly less cracks. To interpret these observations, this paper conjectures that a longer drying protocol favors the formation of aggregates. It is further argued that the number and size of the aggregates increase as the drying rate decreases. This results in the formation of a more disordered, porous film from the viewpoint of the particle packing, and a more resistant film, i.e. less cracks, from the macroscale viewpoint.

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“…As water evaporates following deposition of the tubulin–MWNT conjugates onto the mica surface, the surface tension and the concentration of the conjugates will increase near the mica surface, causing the resulting conjugate film to decrease in thickness and increase in viscosity 27. Thus, the electrostatic and hydrophobic and hydrophilic effects among discrete conjugates, and between the conjugates and the mica surface, will increase 28. The scale of pattern formation will be a function of the rate of evaporation 29.…”

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Tubulin Encapsulation of Carbon Nanotubes into Functional Hybrid Assemblies

Dinu

Bale

Zhu

et al. 2009

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Functional multi‐walled carbon nanotubes (MWNTs) are obtained by conjugation of MWNTs with tubulin. In vitro polymerization of tubulin–MWNT conjugates with excess free tubulin results in the microtubules encapsulating the MWNTs to yeild nanotube‐based biohybrids. The functional biohybrids are manipulated on kinesin‐coated surfaces. This strategy represents a new paradigm for the design of hierarchical supramolecular assemblies.

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Cited by 26 publications

References 6 publications

Heterogeneity in Desiccated Solutions: Implications for Biostabilization

Heterogeneity in Desiccated Solutions: Implications for Biostabilization

Role of evaporation rate on the particle organization and crack patterns obtained by drying a colloidal layer

Tubulin Encapsulation of Carbon Nanotubes into Functional Hybrid Assemblies

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