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Nevskaya, E. Yu.; Горичев, И. Г.; Safronov, S. B.; Зайцев, Б. Е.; Kutepov, A. M.; Изотов, А. Д.

doi:10.1023/a:1012386322832

Cited by 5 publications

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“…We believe that such particles/species/clusters, if at all formed, might get destroyed by the ammonia remnants emanating from the amidine substrates used in the reaction. It is also known that none of the copper oxides survive in ammonia solutions. , …”

Section: Resultsmentioning

confidence: 99%

Cu(II)–Glucose: Sustainable Catalyst for the Synthesis of Quinazolinones in a Biomass-Derived Solvent 2-MethylTHF and Application for the Synthesis of Diproqualone

Dubey

Kumar

2018

ACS Sustainable Chem. Eng.

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An efficient method for the synthesis of quinazolinones by a domino cross-coupling reaction of 2-halobenzoic acids and amidines is demonstrated for the first time using a copper–glucose combination as an inexpensive catalytic system in a biomass-derived green solvent 2-methylTHF. Here, glucose plays a dual role, both as a reducing agent generating the low-valent copper ions from cupric precursors and as a chelating agent of the generated low-valent copper species, thereby impeding their deactivation. A wide variety of quinazolinones were synthesized in good to excellent yields. Notably, the activation of less reactive 2-bromo/chlorobenzoic acids by the catalyst not only advocates the efficiency of the developed protocol but also the broad substrate scope. Moreover, the developed methodology was successfully applied to the synthesis of the drug molecule diproqualone. The UV–vis spectrophotometric titration study of cupric and cuprous salts with glucose showed evidence of glucose playing the role as a ligand, thus it may act as a stabilizing agent for the low valent copper species formed in the reaction. The use of inexpensive and air stable cupric salts along with glucose for the synthesis of quinazolinones in a green solvent makes this a benign and sustainable method.

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Section: Resultsmentioning

confidence: 99%

Cu(II)–Glucose: Sustainable Catalyst for the Synthesis of Quinazolinones in a Biomass-Derived Solvent 2-MethylTHF and Application for the Synthesis of Diproqualone

Dubey

Kumar

2018

ACS Sustainable Chem. Eng.

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Asymmetric ceramic hollow fibres applied in heterogeneous catalytic gas phase reactions

et al. 2012

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Development of a catalytic hollow fibre membrane micro-reactor for high purity H2 production

Rahman

García-García

Hatim

et al. 2011

Journal of Membrane Science

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This article describes development of a catalytic hollow fibre membrane micro-reactor (CHFMMR) for high purity H 2 production. Asymmetric Al 2 O 3 hollow fibres produced by a phase-inversion and sintering technique were employed as a single substrate for both coating of the Pd membrane and impregnation of the 30%CuO/CeO 2 catalyst. The Pd membrane was first deposited onto the outer layer of Al 2 O 3 hollow fibre using the electroless plating (ELP) technique, followed by impregnation of the 30%CuO/CeO 2 catalyst into the inner finger-like structure of the substrate using the sol-gel Pechini method. Performance of the proposed reactor was carried out using water gas shift (WGS) reaction as a sample reaction. A comparative study of conversion obtained in the WGS reaction as a function of the reaction temperature (from 200 o C to 500 o C) in a fixed-bed reactor, a catalytic hollow fibre micro-reactor (CHFMR) and the CHFMMR using different flow rates of a sweep gas (from 45 to 70ml/min) was performed, concluding that the conversion is the highest in the CHFMMR. It is important to highlight that, at 500ºC and a sweep gas flow rate of

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Cited by 5 publications

References 0 publications

Cu(II)–Glucose: Sustainable Catalyst for the Synthesis of Quinazolinones in a Biomass-Derived Solvent 2-MethylTHF and Application for the Synthesis of Diproqualone

Cu(II)–Glucose: Sustainable Catalyst for the Synthesis of Quinazolinones in a Biomass-Derived Solvent 2-MethylTHF and Application for the Synthesis of Diproqualone

Asymmetric ceramic hollow fibres applied in heterogeneous catalytic gas phase reactions

Development of a catalytic hollow fibre membrane micro-reactor for high purity H2 production

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