The bulbospinal monoaminergic system of the chick: degeneration in the sympathetic nucleus following surgical and chemical lesions

Smolen, Arnold J.; Ross, Leonard L.

doi:10.1016/0006-8993(78)90067-7

Cited by 10 publications

(2 citation statements)

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“…In a hypothesis based on neurophysiological studies it has been postulated that the neuropeptides and monoamines probably influence the activity of the preganglionic sympathetic neurons (see Hare et al, 1972;Baum and Shropshire, 1975;Taylor and Brody, 1976;Cabot er al., 1979;Guyenet and Cabot, 1981;Felpel and Huffman, 1982;Gilbey et al, 1983;Caverson et al, 1983;Kadzielawa, 1983;Sangdee and Franz, 1983;McCall, 1988). It is of additional importance that the monoamine and peptide nerve terminals have been shown to belong to descending axons in the lateral funiculus of the spinal cord (Lfu), originating from the brain stem and especially from the medulla oblongata as originally described by Dahlstrom and Fuxe (1965); these observations have been confirmed and extended in a number of subsequent papers (Basbaum et al, 1978;Smolen and Ross, 1978;Lindvall and Bjorklund, 1978;Amendt er al., 1979;Loewy et al, 1979;Westlund and Coulter, 1980;Loewy and McKellar, 1981;Ross et a/. , 1984;Johansson et a/.…”

Section: Introductionmentioning

confidence: 80%

Monoaminergic and Peptidergic Innervation of the Intermedio‐Lateral Horn of the Spinal Cord

Fuxé

Tinner

Bjelke

et al. 1990

Eur J of Neuroscience

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In the rat the monoaminergic and neuropeptidergic innervation of the sympathetic visceral nuclei of the entire thoracic spinal cord has been analysed in serial horizontal sections using immunocytochemistry. Tyrosine hydroxylase (TH), Phenyl-ethanolamine-N-methyl-transferase (PNMT), 5-hydroxytryptamine (5-HT), substance P (SP) and enkephalin (ENK) immunoreactive (IR) nerve terminals form tufts of plexa with strong IR in the principal part of the intermediolateral nucleus (ILp) with the terminals in an extraperikaryal location. High densities of these strongly IR terminals are also found in the principal part of the intercalated nucleus (ICp) and in the paraependymal part of the intercalated nucleus (ICpe). The various types of IR nerve terminals also form rostro-caudally oriented and latero-medially oriented strands of strongly IR nerve terminals at regular intervals within each segment. Outside these sympathetic nuclei the terminals are absent or only weakly to moderately IR. The similar pattern of monoamine and peptide innervation of the putative preganglionic sympathetic neurons along the entire thoracic spinal cord may be related to the general three dimensional architecture of the preganglionic multipolar neurons. Thus, these inputs tend to cover the entire surface area of the preganglionic neurons in a uniform way. Some heterogeneities have been observed for the TH, PNMT and neuropeptide Y (NPY) innervation which may contribute to a differential control of sympathetic preganglionic neurons. It is suggested that the unique features of the descending monoaminergic or peptidergic neurons to sympathetic spinal nuclei are related to a demand for maintained transmission upon prolonged activation in these cardiovascular systems, allowing the maintenance of cardiovascular homeostasis.

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Section: Introductionmentioning

confidence: 80%

Monoaminergic and Peptidergic Innervation of the Intermedio‐Lateral Horn of the Spinal Cord

Fuxé

Tinner

Bjelke

et al. 1990

Eur J of Neuroscience

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“…Using histofluorescence techniques these workers concluded that serotonergic ter-minals located in the sympathetic preganglionic cell column have their cells of origin in the medullary raphe. The presence of serotonin within the column has been confirmed biochemically (3), and electron microscopic evidence from the avian spinal cord suggests that presumed serotonergic terminals on SPN's degenerate after either systemic injection of 5,7-dihydroxytryptamine or spinal transection (4). There are many data implicating the raphe in the neural control of the cardiovascular system by virtue of its location within the medial medullary "depressor area" (5,6).…”

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confidence: 95%