62 Over-The-Scope-Clips Versus Standard Endoscopic Therapy in Patients With Recurrent Peptic Ulcer Bleeding and a Prospective Randomized, Multicenter Trial (Sting)

Schmidt, Arthur; Goelder, Stefan; Messmann, Helmut; Goetz, Martin; Kratt, Thomas; Meining, Alexander; Birk, Michael; Delius, Stefan von; Albért, J; Escher, Monica; Lau, James Y.; Hoffman, Arthur; Wiest, Reiner; Caca, Karel

doi:10.1016/j.gie.2017.03.043

Cited by 12 publications

(7 citation statements)

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“…A multicentre randomised control trial comparing through-the-scope clips (TTSC) with OTSC has recently been reported, 43 In that study, 32 patients received TTSC and 33 received OTSC. Initial haemostasis was reported in 62.5% of those who received TTSC and 96.8% received OTSC (P=0.002).…”

Section: Consensus Statementsmentioning

confidence: 99%

Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018

Sung

Chiu

Chan

et al. 2018

Gut

201

210

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Non-variceal upper gastrointestinal bleeding remains an important emergency condition, leading to significant morbidity and mortality. As endoscopic therapy is the ’gold standard' of management, treatment of these patients can be considered in three stages: pre-endoscopic treatment, endoscopic haemostasis and post-endoscopic management. Since publication of the Asia-Pacific consensus on non-variceal upper gastrointestinal bleeding (NVUGIB) 7 years ago, there have been significant advancements in the clinical management of patients in all three stages. These include pre-endoscopy risk stratification scores, blood and platelet transfusion, use of proton pump inhibitors; during endoscopy new haemostasis techniques (haemostatic powder spray and over-the-scope clips); and post-endoscopy management by second-look endoscopy and medication strategies. Emerging techniques, including capsule endoscopy and Doppler endoscopic probe in assessing adequacy of endoscopic therapy, and the pre-emptive use of angiographic embolisation, are attracting new attention. An emerging problem is the increasing use of dual antiplatelet agents and direct oral anticoagulants in patients with cardiac and cerebrovascular diseases. Guidelines on the discontinuation and then resumption of these agents in patients presenting with NVUGIB are very much needed. The Asia-Pacific Working Group examined recent evidence and recommends practical management guidelines in this updated consensus statement.

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Section: Consensus Statementsmentioning

confidence: 99%

Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018

Sung

Chiu

Chan

et al. 2018

Gut

201

210

View full text Add to dashboard Cite

show abstract

“…In a multicentre randomised controlled trial,19 Schmidt et al compared the use of over-the-scope-clips (OTSC) to standard treatments mostly through the scope clips in the endoscopic treatment of ulcers with refractory bleeding. OTSCs were much more superior in the control of bleeding (15 of 26 vs 30 of 33, p=0.005).…”

Section: Discussionmentioning

confidence: 99%

Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial

Lau

Pittayanon

Wong

et al. 2018

Gut

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show abstract

“…Schmidt et al presented final results of the STING trial that enrolled patients with refractory bleeders. The rate of freedom from rebleeding with use of OTSC at day 30 was significantly higher (30.8 % vs 78 %; P = 0.004) 20 when compared to conventional treatment with either thermal methods or hemo-clips. We eagerly await publication of the full results.…”

mentioning

confidence: 93%

Can we now recommend OTSC as first-line therapy in case of non-variceal upper gastrointestinal bleeding?

Chan

Lau

2017

Endosc Int Open

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62 Over-The-Scope-Clips Versus Standard Endoscopic Therapy in Patients With Recurrent Peptic Ulcer Bleeding and a Prospective Randomized, Multicenter Trial (Sting)

Cited by 12 publications

References 0 publications

Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018

Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018

Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial

Can we now recommend OTSC as first-line therapy in case of non-variceal upper gastrointestinal bleeding?

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