Abstract:The AMPK-related kinase NUAK2 is considered to play some role in melanoma development and progression. In our past studies, we showed that NUAK2 is a gene that has a prognostic significance in acral melanoma patients by verifying a public array comparative genomic hybridization (CGH) database and immunohistochemistry of 56 primary acral melanomas (PNAS, 2011) and that pharmacologic inhibition of CDK2 is sufficient to suppress the growth of NUAK2 amplified and PTEN-deficient melanoma cells (Cancer Res, 2015). T… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.