602 The level of fecal calprotectin in children with refractory celiac disease

Abstract

amounted to 6.9+2.3 pg/ml at a normal rate -4.3+0.7 pg/ml (p<0.05), but the highest increase was observed in IL1b (10.4 +3.9 pg/ml and 2.05+0.03 pg/ml, respectively, p<0.05), which reflects the increased activity of macrophages involved in maintaining the inflammatory process. Thus, the data obtained demonstrate that the intestinal microvascular endothelium of the intestinal mucosa can respond to locally generated cytokines and produce strong pro-inflammatory mediators. Conclusion Thus, there is clear evidence of intestinal inflammation in children with a mixed form of cystic fibrosis, which can negatively affect the patient's nutritional status, which in turn adversely affects pulmonary function and survival. The data obtained are the basis for optimizing therapy aimed at improving bowel function.