60 Maternal Deaths From Pregnancy Associated Liver Diseases-Under-Reported or Under-Recognized in India

Kd, Jamwal; Goel, Ashish; Sajith, KG; Zachariah, UG; Ramachandran, J.; Eapen, CE

doi:10.1016/s0973-6883(12)60061-9

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 On analysing the published data regarding liver dysfunction in pregnancy in India, [13][14][15][16][17][18] it appears that pregnancy-related liver disorders contribute to maternal mortality all over India, but are under-recognised. 19 As mentioned earlier, at our center from 1999 to 2011 we had 285 maternal deaths and 113,755 pregnancies; of these of maternal deaths 8% were due to pregnancy related liver disorders (i.e 23 patients) and 6%; 17of whom (7 had histological confirmation) had AFLP. AFLP is an example of mitochondrial hepatopathy (similar to Reye's syndrome and toxicity due to drugs like valproic acid) and is attributed to a defect in mitochondrial beta oxidation of fatty acids.…”

Section: Acute Fatty Liver Of Pregnancy (Aflp)mentioning

confidence: 77%

Pregnancy-Related Liver Disorders

Goel

Jamwal

Ramachandran

et al. 2014

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

Pregnancy-related liver disorders accounted for 8% of all maternal deaths at our center from 1999 to 2011. Of the three pregnancy-related liver disorders (acute fatty liver of pregnancy (AFLP), HELLP (Hemolysis, elevated liver enzymes, low platelets) syndrome and pre-eclamptic liver dysfunction, which can lead to adverse maternal and fetal outcome, AFLP is most typically under -diagnosed. Risk of maternal death can be minimised by timely recognition and early/aggressive multi-specialty management of these conditions. Urgent termination of pregnancy remains the cornerstone of therapy for some of these life threatening disorders, but recent advancements in our understanding help us in better overall management of these patients. This review focuses on various aspects of pregnancy-related liver disorders. ( J CLIN EXP HEPATOL 2014;4:151-162) A ny liver disorder can occur co-incidentally in pregnancy. Pregnancy can also occur in a patient with pre-existent chronic liver disorder/portal hypertension. In addition, liver dysfunction in pregnancy can also be secondary to pregnancy (i.e. pregnancy-related liver disorders). The 5 pregnancy-related liver disorders-acute fatty liver of pregnancy (AFLP), HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), pre-eclamptic liver dysfunction, intrahepatic cholestasis of pregnancy (ICP) and hyperemesis gravidarum-occur in different gestational time periods.

show abstract