With the growth of data-intensive artificial intelligence models and the roll-out of high-capacity 5G telecom networks, the use of ultra fast transceivers with low power consumption has become essential in data centres. Quantum-confined Stark effect (QCSE) modulators are one of the contender systems that offer the potential to achieve optical modulation at high data rate, whilst retaining low real estate, low power consumption and operation in the O-band. Such modulators can be fabricated using complementary metal-oxide semiconductor (CMOS) materials including Ge/SiGe multiple quantum-well (MQW) stacks grown on silicon (Si), and be integrated with silicon nitride (SiN) on a Si substrate to retain CMOS compatibility and potential for large scale manufacturing. Here we demonstrate an O-band 2.5×50 µm2 Ge/SiGe QCSE modulator butt-coupled to SiN waveguides on Si and silicon-on-insulator (SOI) substrates. With this novel waveguide integration technique and a high-index contrast waveguide interface that utilises anti-reflective coatings, coupling losses of less than 1 dB were achieved along with better than −13.58 dB back-reflection in the O-band. The static extinction ratio (ER) of the modulator remained unchanged in a 20-80 ◦C range achieving in excess of 5 dB, with a 3.01 dB dynamic ER at 50 Gb/s using an on-off keying (OOK) modulation scheme. The modulator also achieved a 100 Gb/s data rate with an ER of 2.28 dB and an average energy consumption of <70 fJ/bit, paving a way to fast and energy-efficient optical interconnects.