6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant

Levy, Arkene; Simon, Oswald; Shelly, J.; Gardener, M.T.

doi:10.1186/1471-2210-6-12

Cited by 79 publications

(47 citation statements)

References 28 publications

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“…28 Using an in vitro and in vivo model system, we found that a water extract of ginger inhibited production of inflammatory mediators. Gingerol and shogaol, which are typical ginger-derived components, have potent anti-inflammatory activity 29,30 and would be expected to have an anti-inflammatory effect in the skin. Keratinocyte defense mechanisms include attraction and activation of leukocytes and lymphocytes, activation of the immune system, and the ensuing effects that these have on blood flow, coagulation, the complement system, and epidermal cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Zingiber officinaleProtects HaCaT cells and C57BL/6 Mice from Ultraviolet B-Induced Inflammation

Guahk

Jung

et al. 2010

Journal of Medicinal Food

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Ultraviolet (UV) light is a physical carcinogen, and UV irradiation from sunlight has negative effects on human skin. UVB-induced inflammation is linked to excessive induction of various inflammatory cytokines/chemokines in many types of cells, including keratinocytes. The purpose of this study was to investigate the anti-inflammatory effect of water extract of Zingiber officinale, gingerol, and shogaol on UVB-induced skin damage in the human keratinocyte cell line HaCaT and C57BL/6 mice. To test for an effective compound to protect against inflammation in UV-damaged skin, we prepared a water extract of ginger rhizomes and examined the effects of Z. officinale, gingerol, and shogaol on cell viability and cytokine/chemokine production in UV-irradiated HaCaT cells. We also investigated the in vivo relevance of these findings in C57BL/6 mice using hematoxylin and eosin staining and cytokine measurements. A water extract of Z. officinale, gingerol, and shogaol inhibited production of cytokines in UVB-irradiated HaCaT cells effectively. Treatment with Z. officinale attenuated UVB-induced hyperplasia, infiltration of leukocytes, and dilation of blood vessels in the dermis of mice. Z. officinale, gingerol, and shogaol show potential as anti-inflammatory agents to protect skin against UVB irradiation damage.

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Section: Discussionmentioning

confidence: 99%

Zingiber officinaleProtects HaCaT cells and C57BL/6 Mice from Ultraviolet B-Induced Inflammation

Guahk

Jung

et al. 2010

Journal of Medicinal Food

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“…In the Complete Freund's Adjuvant monoarthritic model, 6-shogaol reduced the inflammatory response and thereby protected the femoral cartilage from damage of the knee joint of rats (Levy et al, 2006). An experimental study was conducted among the senior citizens of Hong Kong for moderate-to-severe knee pain by aroma-massage therapy with aromatic ginger and orange essential oil over a three week period (Yin et al, 2008) and found that the aroma-massage therapy seems to have potential as an alternative method for short-term knee pain relief.…”

Section: Effect Of Ginger On Knee Jointmentioning

confidence: 97%

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Kubra

Rao

2012

Critical Reviews in Food Science and Nutrition

158

118

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Ginger rhizome (Zingiber officinale Roscoe) is widely cultivated as a spice for its aromatic and pungent components. The essential oil and oleoresins from ginger are valuable products responsible for the characteristic flavor and pungency. Both are used in several food products such as soft beverages and also in many types of pharmaceutical formulations. More than 100 compounds have been reported from ginger, some of which are isolated and characterized, others are tentatively identified by GC-MS and / or LC-MS. [6]-Gingerol, the major gingerol in ginger rhizomes, has been found to possess many interesting pharmacological and physiological activities, such as anti-inflammatory, analgesic, and cardiotonic effects. Ginger is considered as "generally recognized as safe" (GRAS) by Food and Drug Administration (FDA), USA. Due to all these properties, ginger has gained considerable attention in developed countries in recent years, especially for its use in the treatment of inflammatory conditions. The present review is a persuasive presentation of the current information on processing, chemistry, biological activities, and medicinal uses of ginger. Further studies are required for the validation of the beneficial uses. Formulation for novel products and new usages may emerge in the years to come, based on the revealed results of various studies.

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“…Shogaols have been actively investigated in numerous studies, of which the majority has been conducted on 6-shogaol. In vitro and in vivo findings have indicated that 6-shogaol exerts anti-inflammatory effects [12,13]. Recently, our laboratory and Weng et al have reported the in vitro anti-invasive effects of 6-shogaol against breast carcinoma and hepatocarcinoma cells respectively [14,15].…”

Section: Introductionmentioning

confidence: 93%

Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

et al. 2011

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Shogaols have been previously reported to induce cancer cell death via multiple mechanisms, among which one analog 6-shogaol has been reported to cause microtubule damage through specific reaction with sulfhydryl groups in tubulin. In this study, a series of shogaols with different side chain lengths (4-, 6-, 8- and 10-shogaol) was synthesized and evaluated for antiproliferative activity in HCT 116 colon carcinoma and SH-SY5Y neuroblastoma cells. 4- and 6-shogaol were identified as lead compounds possessing the strongest antiproliferative activity. In the soft agar assay, the lead shogaols displayed dose-dependent inhibition on cancer cell colony formation under anchorage-independent conditions. Using HCT 116 as the selected cancer cell line, the molecular events linking shogaols-induced G(2)/M cell cycle arrest to apoptosis characterized by caspase 3 and PARP cleavage were investigated. At sublethal concentrations, the halt at G(2)/M phase was alleviated along time and cells survived. Conversely, proapoptotic concentrations of 4- and 6-shogaol induced irreversible G(2)/M arrest that was at least in part associated with down-regulation of cell cycle checkpoint proteins cdk1, cyclin B and cdc25C, as well as spindle assembly checkpoint proteins mad2, cdc20 and survivin. A dose- and time-dependent accumulation of insoluble tubulin in the insoluble fractions of cell lysates provided evidence that G(2) checkpoint failure led to disruption of microtubule turnover. In summary, our results conclude that shogaols cause apoptosis by inducing aberrant mitosis at least through the attenuation of cell cycle and spindle assembly checkpoint proteins.

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6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant

Cited by 79 publications

References 28 publications

Zingiber officinaleProtects HaCaT cells and C57BL/6 Mice from Ultraviolet B-Induced Inflammation

Zingiber officinaleProtects HaCaT cells and C57BL/6 Mice from Ultraviolet B-Induced Inflammation

An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinaleRoscoe)

Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation

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