6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Isa, Yasuka; Miyakawa, Yuri; Yamaguchi, Masayoshi; Goto, Tsuyoshi; Kang, Min‐Sook; Kawada, Teruo; Morimitsu, Yasujiro; Kubota, Kikue; Tsuda, Takanori

doi:10.1016/j.bbrc.2008.06.046

Cited by 140 publications

(92 citation statements)

References 27 publications

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“…This metabolic change occurs via peroxisome proliferator-activated receptors (PPAR), which are involved in adipocyte differentiation [20] [21] [22] [23]. One of the components of GP, 6-shogaol, has been proven to activate PPAR [24]. Hence, the unchanged liver weight of mice in the GP groups compared with those of mice in the HFD group observed in this present study might be due to increased PPAR-stimulated hepatic peroxisome induction.…”

Section: Discussionmentioning

confidence: 78%

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity

Hattori¹,

Yamauchi²,

Onwona-Agyeman³

et al. 2017

AJPS

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The methanol extract of grains of paradise (GP), the seed of Aframomum melegueta, which is distributed throughout West Africa, was administered during an animal breeding test. The extract suppressed body weight gain and decreased the weight of adipose tissues in breeding mice, with a greater effect on mice fed a high-fat diet (HFD) than on those fed a normal diet (ND). Other significant effects of GP intake included increased serum triglyceride (TG) concentration and reduced hepatic total cholesterol (TC) and TG concentrations. GP intake markedly prevented fat accumulation and improved hepatic lipid metabolism in HFD-fed mice. In addition, GP extract at a dosage of 5 mg/kg body weight decreased sympathetic nerve activity (SNA) in brown adipose tissue (BAT), while capsaicin, a major component of chili pepper, activated BAT SNA. This suggested that GP exerts a potential anti-obesity effect by a different mechanism from that of capsaicin.

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Section: Discussionmentioning

confidence: 78%

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity

Hattori¹,

Yamauchi²,

Onwona-Agyeman³

et al. 2017

AJPS

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“…It is traditionally used for the treatment of rheumatism, nervous diseases, gingivitis, toothache, asthma, constipation, diabetes, and arthritis [21]. It has phytoconstituents that have anti-inflammatory, anti-oxidant and anticancer effects [22,23]. P. spicigera, from the family Leguminosae, is not an extensively studied plant as not much literature is available.…”

Section: Discussionmentioning

confidence: 99%

Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains

Khan

Zakir

Afaq

et al. 2010

J Infect Dev Ctries

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Background: The emerging trends of multidrug resistance among several groups of microorganisms against different classes of antibiotics led different researchers to develop efficient drugs from plant sources to counter multidrug resistant strains. This study investigated different solvent extracts of Prosopis spicigera (P. Spicigera), Zingiber officinale, and Trachyspermum ammi (T. ammi) to determine their efficacy against multidrug resistant microbes. Methodology: Successive extractions of these plants were performed using a Soxhlet apparatus, using solvents with increasing polarities. Preliminary phytochemical analysis was also performed .Minimum inhibitory concentration was determined by a two-fold serial dilution method followed by determination of minimum bactericidal/fungicidal concentration. Multidrug resistant (MDR) strains of Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Escherichia coli and reference strains of Streptococcus mutans and Streptococcus bovis were used in the study. Results: The ethanolic fraction of P. spicigera (least minimum inhibitory concentration [MIC] -4.88 µg/ml) demonstrated a remarkable inhibition of the microorganisms while fractions obtained from those of Zingiber officinale (least MIC-78.125 µg/ml) exhibited little activity. The petroleum ether fraction of T. ammi (least MIC-625 µg/ml) showed best activity when compared to its other fractions. Qualitative analysis of the phytoconstituents was also performed. Conclusions: The potency shown by these extracts recommends their use against multidrug resistant microorganisms. This study also showed that P. spicigera could be a potential source of new antimicrobial agents.

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“…However, this is bound to be an oversimplification, since pharmacokinetic studies are needed to determine concentrations in different organs and cell compartments, whilst the optimal therapeutic effects may be contributed by multiple activities. Other mechanisms of Zingiber officinale and its components include upregulation of adiponectin by 6-shogaol and 6-gingerol and PPAR-agonistic activity of 6-shogaol (but not 6-gingerol) [113], activation of hepatic cholesterol-7 -hydroxylase to stimulate the conversion of hepatic cholesterol to bile acids [114,115], increase in the faecal excretion of cholesterol and possible block of absorption of cholesterol in the gut [116], and inhibition of cellular cholesterol biosynthesis described in an apolipoprotein E-deficient mouse [117]. Other possible effects are related to its COX2 actions in diabetic chronic inflammation and effects on carbohydrate through inhibition of hepatic phosphorylase (to prevent the glycogenolysis in hepatic cell) and increase of enzyme activities contributing to progression of glycogenesis and inhibition of the activity of hepatic glucose-6-phosphatase (thereby decreasing glucose phosphorylation and contributing to lowering blood glucose) [40].…”

Section: The Multiple Targets Of Ginger Actionmentioning

confidence: 99%

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Roufogalis

2014

New Journal of Science

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Diabetes is reaching pandemic levels in both developing and developed countries and requires safe, affordable, and effective therapies. This report summarises work in our laboratory on the effects of Zingiber officinale (ginger) and its components in diabetes models and provides a future outlook on the potential for their use in type 2 diabetes. A high fat diet rat model showed modulation of body weight gain and normalisation of glucose and lipid metabolic disturbances, with reduction of insulin resistance in a high fat-high carbohydrate diet model. Ginger extract inhibits enhanced NF-B in liver of high fat-fed rats through inhibition of the IKK/I B /NF-B classical pathway. The major active component (S) -[6]-gingerol inhibited elevated cytokines in inflamed HuH-7 cells through suppression of COX2 expression and protection against the ROS pathway. Ginger extract and gingerols enhanced glucose uptake in L6 myotubes, by enhancing translocation of GLUT4 to the surface membrane and activation of AMPK 1 through a Ca 2+ /calmodulin-dependent protein kinase kinase pathway. (S)-[6]-Gingerol also enhanced energy metabolism through marked increment of peroxisome proliferator-activated receptor-coactivator-1 (PGC-1 ) gene expression and mitochondrial content in L6 skeletal muscle cells. Future studies will require well designed clinical trials on ginger preparations of defined chemical composition.

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6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Cited by 140 publications

References 27 publications

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity

Effect of Grains of Paradise (GP) Extract Intake on Obesity and Sympathetic Nerve Activity

Activity of solvent extracts of Prosopis spicigera, Zingiber officinale and Trachyspermum ammi against multidrug resistant bacterial and fungal strains

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

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