6‐O glucose linoleate supports <i>in vitro</i> human hair growth and lipid synthesis

Vingler, Philippe; Gautier, Brigitte; Dalko, Maria; Rozot, Roger; Gaillard, O; Michelet, Jean‐François; Bernard, Bruno

doi:10.1111/j.1467-2494.2007.00356.x

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…In addition, the demand for glucose of hair follicles from different regions is inconsistent. Generally, the growth of hair follicles on the head has a higher energy requirement, which is related to the metabolism of glucose and glucose derivatives [ 46 , 47 ]. Moreover, the glucose sensitivity of stem cells activation and differentiation are inconsistent [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

Wang

Yao

et al. 2022

Journal of Diabetes Research

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Background. Hair follicles are important accessory organs of the skin, and it is important for skin renewal and performs variety of important functions. Diabetes can cause several dermatoses; however, its effect on hair follicles is unclear. The purpose of this study was to investigate the effect of type II diabetes (T2DM) on the hair follicles of mice. Methods. Seven-week-old male C57BL/6 littermate mice were divided into two groups. The treatment group was injected with streptozotocin (STZ) to induce T2DM, and the control group was parallelly injected with the same dose of buffer. Seven days after injection, the back is depilated to observe the hair follicle regeneration. Hair follicle regeneration was observed by naked eyes and HE staining. The proliferation of the skin cells was observed by PCNA and K14 staining. The altered genes were screened by RNA sequencing and verified by qRT-PCR. In addition, Lgr5 + GFP/mTmG transgenic mice were used to observe the effect of T2DM on Lgr5 hair follicle stem cells (HFSC). And the expression of WNT4 and WNT8A were measured by Western Blot. Results. T2DM inhibited hair follicle regeneration. Compared to control mice, T2DM mice had smaller hair follicles, reduced skin thickness, and less expression of PCNA and K14. RNA sequencing showed that the two groups had significant differences in cell cycle and proliferation-related pathways. Compared with the control mice, the mRNA expression of Lgr4, Lgr5, Wnt4, and Wnt8a was decreased in the T2DM group. Moreover, T2DM inhibited the activation of Lgr5 HFSC and the expression of WNT4 and WNT8A. Conclusions. T2DM inhibited hair follicle regeneration and skin cells proliferation by inhibiting WNT-dependent Lgr5 HFSC activation. This may be an important reason for the reduction of skin renewal ability and the formation of chronic wounds caused by diabetes. It is important for the treatment of chronic diabetic wounds and the development of tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

Wang

Yao

et al. 2022

Journal of Diabetes Research

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“…Nevertheless, we believe, that when regarding treatment outcomes observed in both women and men, AC5 used in monotherapy and under the study conditions confirmed that combining several ingredients, known for their clinical benefit, notably reduces hair loss. [15][16][17][18] Despite these limitations, AC5 improves hair loss and hair quality in subjects with mild AGA with an excellent tolerability, a pleasant texture, and a high satisfaction rate.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14] Arginine was shown to improve microvascular function in the skin, piroctone olamine to increase hair shaft thickness, SP94 to fortify hair fibers, and VVMW to reduce skin inflammation. [15][16][17][18] Moreover, yet unpublished data have provided evidence that piroctone olamine, as VVMW, decreases inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…DPNO has shown a strong anti‐lysyl hydroxylase activity in vitro as well as its benefit in subjects with mild AGA 11–14 . Arginine was shown to improve microvascular function in the skin, piroctone olamine to increase hair shaft thickness, SP94 to fortify hair fibers, and VVMW to reduce skin inflammation 15–18 . Moreover, yet unpublished data have provided evidence that piroctone olamine, as VVMW, decreases inflammation.The aim of this cosmetic study was to assess hair loss improvement and hair quality with AC5 in subjects with mild AGA in real‐life settings.…”

Section: Introductionmentioning

confidence: 99%

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An anti‐hair loss treatment in the management of mild androgenetic alopecia: Results from a large, international observational study

Reygagne

Mandel

Delva³

et al. 2021

Dermatologic Therapy

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Androgenic alopecia (AGA) is a common and chronic condition. It may impact selfesteem, self-image and quality of life. Benefit, tolerability, cosmetic acceptance and patient satisfaction are key to ensure good treatment outcome. Hair loss improvement and hair quality with AC5 (2,4-Diamino-Pyrimidine-N-Oxyde, arginine, 6-O glucose linoleate (SP94), piroctone olamine and Vichy mineralizing water) once daily was assessed in 527 subjects with mild AGA in an open-label, observational, international real-life study. After 3 months, investigators evaluated the impact of AC5 on hair loss, product satisfaction and asked subjects about local tolerance; subjects assessed hair growth and quality and satisfaction. Data from 357 subjects were evaluable for the benefit analysis; 59.9% of subjects were female; the mean age was 33.6±8.7 years. Duration of hair loss was 1.62±2.24 years. 71.3% of women had a Ludwig score of 1 and 40.8% of men had a Hamilton Norwood score of 2. At the end of study, hair loss was reduced in 89.0% of subjects; it was slightly higher in women (92.5%) than in men (83.8%). Subject satisfaction on a scale from 0 (not satisfied at all) to 10 (completely satisfied) was 7.9±1.7. Tolerance was rated good to very good by 98.6% of all subjects. In conclusion, AC5 reduces mild AGA in both men and women with a pleasant texture. AC5 was well tolerated and highly appreciated.

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“…This model allowed the factors that govern hair growth, hair structure and its 3D shape to being better characterized. [117][118][119][120][121]…”

Section: The Facial Appearance: the "Raison D'être" Of Cosmetic Researchmentioning

confidence: 99%

Skin cancer: an overview regarding treatment and its cosmetic repair

Bernard

Léger

Leclaire

2018

JDC

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Introduction: Beauty, a scientific challenge?"Appearance rules the world". Friedrich Schiller .The question of beauty reality and truth was raised by the Journal "Nature" in a few articles (Supplements in vol. 526, October 2015). It indeed may well surprise laymen, as mathematicians, physicists, astronomers, biologists, geneticists…are commonly perceived as gatekeepers of objectivity and accuracy. As the latter terms hardly apply to beauty, attempting to give it a clear-cut definition, under authoritative statements, comes utopic for many reasons.Even if beauty is real and influent, its definition remains puzzling. At first, the very term beauty applies in common conversations to a wide range of very different elements (a human face, a baby, a landscape, and an animal, a vegetal...). Second, its roots are much anchored within ethnic cultures, history, fashions…and its perception is thought dictated by a central region of the brain (amygdala), i.e. the epicentre of "aesthetic brains". 1 In brief, the perception of beauty, anchored within the human conscience, undoubtedly strives emotions. However, beauty may own an objective part, according to physicist D Deutsch 2 who takes the beauty of flowers as his favourite example: these are attractive to insects (the objective part/pollination) and humans (their subjective part) through shape, colour, and fragrances. 2 The standards of this beauty objective part are subjected to permanent improvements, like in science. The "beautiful" Newton theory was a first standard that was further enclosed and enlarged by another "beautiful" Einstein theory, like two successive Russian dolls. In both cases of beauty and science, standards' improvements tend to reach an objective truth.

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6‐O glucose linoleate supports in vitro human hair growth and lipid synthesis

Cited by 7 publications

References 23 publications

Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

An anti‐hair loss treatment in the management of mild androgenetic alopecia: Results from a large, international observational study

Skin cancer: an overview regarding treatment and its cosmetic repair

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