6-O-endosulfatases in tumor metastasis: heparan sulfate proteoglycans modification and potential therapeutic targets
Mengzhen Han
Abstract:Metastasis is the leading cause of cancer-associated mortality. Although advances in the targeted treatment and immunotherapy have improved the management of some cancers, the prognosis of metastatic cancers remains unsatisfied. Therefore, the specific mechanisms in tumor metastasis need further investigation. 6-O-endosulfatases (SULFs), comprising sulfatase1 (SULF1) and sulfatase 2 (SULF2), play pivotal roles in the postsynthetic modifications of heparan sulfate proteoglycans (HSPGs). Consequently, these extr… Show more
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