6-Month Versus 12-Month Dual-Antiplatelet Therapy Following Long Everolimus-Eluting Stent Implantation

Abstract

Compared with 12-month DAPT, 6-month DAPT did not increase the composite events of cardiac death, myocardial infarction, stroke, or TIMI major bleeding at 1 year in patients who underwent everolimus-eluting stent implantation. (Impact of Intravascular Ultrasound Guidance on Outcomes of XIENCE PRIME Stents in Long Lesions [IVUS-XPL Study]; NCT01308281).

Efficacy and safety of short‐term dual antiplatelet therapy (≤6 months) after percutaneous coronary intervention for acute coronary syndrome: A systematic review and meta‐analysis of randomized controlled trials

“…Among the 10 trials, 3 trials exclusively enrolled ACS patients . The other seven trials enrolled both stable angina and ACS patients with reported outcomes for the ACS subgroup . The majority of studies were open‐label, noninferiority trials that used clopidogrel as the second antiplatelet agent.…”

“…9,17,18 The other seven trials enrolled both stable angina and ACS patients with reported outcomes for the ACS subgroup. 3,7,8,[22][23][24][25] The majority of studies were open-label, noninferiority trials that used clopidogrel as the second antiplatelet agent. Second-generation DESs were used in most patients and every trial recommended aspirin monotherapy following the completion of short-term DAPT.…”

Outcomes of ≤6-month versus 12-month dual antiplatelet therapy after drug-eluting stent implantation

“…1). Finally, 9 RCTs [14–22] satisfied inclusion criteria, all of which were published in English language journals as full manuscripts. The primary characteristics of included trials are presented in Table 1.…”

Critical appraisal of guidelines for coronary artery disease on dual antiplatelet therapy: More consensus than controversies

“…14,38 Premature discontinuation of DAPT before standard duration may lead to stent thrombotic events, [39][40][41] while shortened duration is associated with lower bleeding rate and non-inferiority cloud be found in several studies. 42 pay more attention to the practical application when they read the guidelines. Applying these tools would make it easier for clinicians to use the DAPT guidelines without many difficulties, which would improve the application of the guidelines and the score of domain 5.…”