6-Month Follow-Up of a Novel Biodegradable Drug-Eluting Stent Composed of Poly-L-Lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery

Xiao, Jing; Feng, Gaoke; Kang, GuanYang; Lan, Zhiyuan; Liao, Tianshi; Kislauskis, Edward H.; Chen, Jiuhao; Xia, Jinxi; Wang, Zhimin; Huo, Zhicheng; Wang, Qun; Xi, Tingfei; McCarthy, Stephen P.; Jiang, Xuejun; Wu, Tingting; Laham, Roger J.

doi:10.1166/jbn.2015.2102

Cited by 9 publications

(6 citation statements)

References 20 publications

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“…The porcine model of restenosis after stenting was generated as our previously described. 22 , 23 After porcine were sacrificed, the coronary arteries were removed from the heart and fixed with 10% formalin, then paraffin embedded and sectioned into 5 μm. The sections were then stained with haematoxylin–eosin, and observed under the microscope.…”

Section: Methodsmentioning

confidence: 99%

“…The total protein from HASMCs was extracted by RIPA as previously described. 3,4 The Pierce™ BCA Protein Assay Kit (23,225,Thermo Fisher Scientific) was used to determine the protein concentration. The protein was denatured at 95 C with 5 Â Loading buffer, 20 μg of total protein was loaded and separated by sodium dodecyl sulphate polyacrylamide gel electrophoresis.…”

Section: Western Blot Analysismentioning

confidence: 99%

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Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation

et al. 2022

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Prevention of neointima formation is the key to improving long-term outcomes after stenting or coronary artery bypass grafting. RNA N 6 -methyladenosine (m 6 A) methylation has been reported to be involved in the development of various cardiovascular diseases, but whether it has a regulatory effect on neointima formation is unknown.Herein, we revealed that methyltransferase-like 3 (METTL3), the major methyltrans-

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Section: Methodsmentioning

confidence: 99%

Section: Western Blot Analysismentioning

confidence: 99%

Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation

et al. 2022

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“…The second generation of BS was composed of biodegradable polymers that generate more innocuous products during their degradation than metallic oxides. One of the most frequently used biodegradable polymers is PLLA due to its high biocompatibility ( Xiao et al, 2015 ). In a period of 12–18 months, PLLA is metabolized into Carbon dioxide and water via the Krebs cycle with no toxic products resulting from the degradation.…”

Section: Coronary Angioplasty and Stent Implantationmentioning

confidence: 99%

Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases

Barungi

Hernández-Camarero²,

Moreno-Terribas³

et al. 2023

Front. Cell Dev. Biol.

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Cardiovascular diseases (CVD) are the leading causes of death and disability in the world. Among all CVD, the most common is coronary artery disease (CAD). CAD results from the complications promoted by atherosclerosis, which is characterized by the accumulation of atherosclerotic plaques that limit and block the blood flow of the arteries involved in heart oxygenation. Atherosclerotic disease is usually treated by stents implantation and angioplasty, but these surgical interventions also favour thrombosis and restenosis which often lead to device failure. Hence, efficient and long-lasting therapeutic options that are easily accessible to patients are in high demand. Advanced technologies including nanotechnology or vascular tissue engineering may provide promising solutions for CVD. Moreover, advances in the understanding of the biological processes underlying atherosclerosis can lead to a significant improvement in the management of CVD and even to the development of novel efficient drugs. To note, over the last years, the observation that inflammation leads to atherosclerosis has gained interest providing a link between atheroma formation and oncogenesis. Here, we have focused on the description of the available therapy for atherosclerosis, including surgical treatment and experimental treatment, the mechanisms of atheroma formation, and possible novel therapeutic candidates such as the use of anti-inflammatory treatments to reduce CVD.

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“… 248 The long-term safety and efficacy evaluation of these stents in porcine revealed minimal restenosis and complete re-endothelialization, with no stent thrombosis. 249 A fully bioresorbable PLLA/ACP nanoparticle composite scaffold containing sirolimus that could release more than 70% of drug within 28 days, and completely degrade the polymer matrix within 2–3 years in vivo , was also studied. This stent showed a similar safety profile as sirolimus-eluting stents, with long-term inhibition of neointimal proliferation in pigs.…”

Section: Introductionmentioning

confidence: 99%

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

et al. 2021

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Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited through the use of the current clinical drug-eluting stent which releases antiproliferative drugs, problems of late-stent thrombosis remain a concern due to polymer hypersensitivity and delayed re-endothelialization. Thus, the field of coronary stenting demands devices having enhanced compatibility and effectiveness to endothelial cells. Nanotechnology allows for efficient modulation of surface roughness, chemistry, feature size, and drug/biologics loading, to attain the desired biological response. Hence, surface topographical modification at the nanoscale is a plausible strategy to improve stent performance by utilizing novel design schemes that incorporate nanofeatures via the use of nanostructures, particles, or fibers, with or without the use of drugs/biologics. The main intent of this review is to deliberate on the impact of nanotechnology approaches for stent design and development and the recent advancements in this field on vascular stent performance.

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6-Month Follow-Up of a Novel Biodegradable Drug-Eluting Stent Composed of Poly-L-Lactic Acid and Amorphous Calcium Phosphate Nanoparticles in Porcine Coronary Artery

Cited by 9 publications

References 20 publications

Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation

Methyltransferase‐like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation

Clinical implications of inflammation in atheroma formation and novel therapies in cardiovascular diseases

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

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