6-Minute Walk Work for Assessment of Functional Capacity in Patients With COPD

Carter, Rick; Holiday, David; Nwasuruba, Chiagozie; Stocks, James M.; Grothues, Carol; Tiep, Brian

doi:10.1378/chest.123.5.1408

Cited by 194 publications

(168 citation statements)

References 25 publications

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“…In patients with lung disease, the 6MWw rate has demonstrated better sensitivity and specificity in identifying exercise intolerance than has 6MWD (14). Recently, Hill et al (15) ergometer test.…”

Section: Introductionmentioning

confidence: 99%

The six-minute walk test and body weight-walk distance product in healthy Brazilian subjects

Iwama

Andrade

Shima

et al. 2009

Braz J Med Biol Res

212

215

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We assessed the 6-min walk distance (6MWD) and body weight x distance product (6MWw) in healthy Brazilian subjects and compared measured 6MWD with values predicted in five reference equations developed for other populations. Anthropometry, spirometry, reported physical activity, and two walk tests in a 30-m corridor were evaluated in 134 subjects (73 females, 13-84 years). Mean 6MWD and 6MWw were significantly greater in males than in females (622 ± 80 m, 46,322 ± 10,539 kg . m vs 551 ± 71 m, 36,356 ± 8,289 kg . m, P < 0.05). Four equations significantly overestimated measured 6MWD (range, 32 ± 71 to 137 ± 74 m; P < 0.001), and one significantly underestimated it (-36 ± 86 m; P < 0.001). 6MWD significantly correlated with age (r = -0.39), height (r = 0.44), body mass index (r = -0.24), and reported physical activity (r = 0.25). 6MWw significantly correlated with age (r = -0.21), height (r = 0.66) and reported physical activity (r = 0.25). The reference equation devised for walk distance was 6MWD m = 622.461 -(1.846 x Age years ) + (61.503 x Gender males = 1; females = 0 ); r 2 = 0.300. In an additional group of 85 subjects prospectively studied, the difference between measured and the 6MWD predicted with the equation proposed here was not significant (-3 ± 68 m; P = 0.938). The measured 6MWD represented 99.6 ± 11.9% of the predicted value. We conclude that 6MWD and 6MWw variances were adequately explained by demographic and anthropometric attributes. This reference equation is probably most appropriate for evaluating the exercise capacity of Brazilian patients with chronic diseases.

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Section: Introductionmentioning

confidence: 99%

The six-minute walk test and body weight-walk distance product in healthy Brazilian subjects

Iwama

Andrade

Shima

et al. 2009

Braz J Med Biol Res

212

215

View full text Add to dashboard Cite

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“…The test has been shown to be an important prognostic factor for outcome independent of the forced expiratory volume in one second (FEV1) [12]. The 6MWD is a submaximal excercise test, but it correlates well with the maximal cardiopulmonary exercise test [13][14][15], and appears to be better tolerated and more reflective of the activities of daily living than other walk tests [16,17].While there is plenty of data concerning the natural history of FEV1 over time, little information has been published regarding the temporal behaviour of the 6MWD. This is a significant omission, as the 6MWD test is frequently used to evaluate the long-term impact of interventions.…”

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confidence: 99%

The 6-min walking distance: long-term follow up in patients with COPD

Casanova¹,

Côté²,

Marı́n³

et al. 2007

European Respiratory Journal

155

105

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The 6-min walking distance (6MWD) test is used in clinical practice and research into patients with chronic obstructive pulmonary disease (COPD). However, little is known about natural long-term change in this parameter.The 6MWD was measured at baseline and then annually for 5 yrs in 294 patients with COPD and its annual rate of decline was determined. Forced expiratory volume in one second (FEV1) was also measured and the relationship between changes in both markers was explored.At baseline, the median 6MWD was 380 m (range 160-600 m). It declined by 19% (16 m?yr -1 ) over the 5 yrs compared with baseline in patients with American Thoracic Society/European Respiratory Society stage III COPD (FEV1 30-50% predicted) and by 26% (15 m?yr -1 ) in patients with stage IV COPD (FEV1 ,30% pred). Over the 5-yr follow-up, the proportion of patients with a minimal clinically significant decline of 54 m increased with the severity of the disease. It was 24% in stage II, 45% in stage III, and 63% in stage IV disease. In contrast, the rate of decline of FEV1 was greater in patients with milder airflow obstruction and lesser in patients with lower absolute FEV1 values.In conclusion, the 6-min walking distance test provides increasingly useful information as the severity of chronic obstructive pulmonary disease increases.KEYWORDS: Chronic obstructive pulmonary disease, 6-min walking distance T he 6-min walking distance (6MWD) test has gained importance in the assessment of functional exercise capacity in patients with chronic obstructive pulmonary disease (COPD) [1,2] Introduced in 1976 as a 12-min walk test to measure the exercise capacity of patients with COPD, the abbreviated 6MWD has proved to be reliable, inexpensive, safe and easy to apply [7][8][9][10]. Furthermore, it correlates well with other important outcomes in COPD patients such as dyspnoea, airway obstruction and lung hyperinflation [11]. The test has been shown to be an important prognostic factor for outcome independent of the forced expiratory volume in one second (FEV1) [12]. The 6MWD is a submaximal excercise test, but it correlates well with the maximal cardiopulmonary exercise test [13][14][15], and appears to be better tolerated and more reflective of the activities of daily living than other walk tests [16,17].While there is plenty of data concerning the natural history of FEV1 over time, little information has been published regarding the temporal behaviour of the 6MWD. This is a significant omission, as the 6MWD test is frequently used to evaluate the long-term impact of interventions. Changes in 6MWD over time have been addressed in one published study [12], but it was limited to patients with severe COPD, the follow-up time was relatively short (1 yr) and the decline trend was established with only two measurements.As part of the large body mass index, degree of obstruction, dyspnoea and exercise capacity (BODE) cohort, the present authors have evaluated the 6MWD systematically as one of several variables included in the evaluation of pati...

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“…Other authors concluded that expressing walked distance in work units improves the accuracy and extension of its usefulness, and it is better correlated with walking performance during the test 29,30 . The work rate measured in the present study did not show significant differences between the tests in the different corridors, with similar energy expenditure between the different proposed lengths.…”

Section: Discussionmentioning

confidence: 99%