6 Hypoglycaemic Drugs

Sarges, Reinhard

doi:10.1016/s0079-6468(08)70320-5

Cited by 7 publications

(1 citation statement)

References 180 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The crystals formed were filtered off and dissolved in a small amount of ethanol, and petroleum ether was added until the solution became turbid. It was left in the refrigerator; the precipitate was filtered off and dried at 100 °C: yield 63%; white crystals; mp 185-186 °C; NMR (CDC13) Í 2.69-2.80 (m, 2 H, NCHü), 3.27-3.40 (m, 2 H, NCH2), 3.75-3.85 (m, 2 H, OCH2), 3.88 (s, 3 H, OCH3), 3.9-4.0 (m, 2 H, OCH2), 4.39 (s, 2 H, SCH2), 5.65 NMR (DMSO-d6) 0.7-0.98 (tt, 3 H, CCH3), 1.39-1.91 (qt, 2 H, CH2), 2.53-2.74 (qt, 2 H, C6CH2), 4.38 (s, 2 H, SCH2, 7.10-7.58 (m, 5 H, ArH). Anal.…”

Section: Methodsmentioning

confidence: 99%

Boron-containing thiouracil derivatives for neutron-capture therapy of melanoma

Tjarks¹,

Gabel²

1991

J. Med. Chem.

View full text Add to dashboard Cite

Boron-containing derivatives of 2-thiouracil and 2,4-dithiouracil and the corresponding 6-propyl compounds, containing a dihydroxyboryl group in the 5-position, have been prepared. These compounds accumulate in B16 melanoma in mice in concentrations up to 30 micrograms of boron per gram tissue. The uptake persists. The toxicity of both 2-thiouracil derivatives is low. These compounds are therefore good candidates for boron neutron-capture therapy of malignant melanoma.

show abstract

Section: Methodsmentioning

confidence: 99%