1974
DOI: 10.1016/0006-8993(74)90888-9
|View full text |Cite
|
Sign up to set email alerts
|

6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

2
16
0

Year Published

1976
1976
2011
2011

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 110 publications
(18 citation statements)
references
References 25 publications
2
16
0
Order By: Relevance
“…Our results that females showed greater cocaine-induced enhancement in locomotor activity are consistent with previous observations in several species that females are more sensitive to the behavioral effects of cocaine (Sell et al, 2000;Schindler and Carmona, 2002). It has been demonstrated that psychostimulant-induced ambulatory behavior and stereotypy are mediated by dopamine (DA) signaling in the nucleus accumbens (Sharp et al, 1987) and the striatum (Asher and Aghajanian, 1974). Thus, sex differences in the DA system in these areas may contribute to the observed effects.…”
Section: Discussionsupporting
confidence: 92%
“…Our results that females showed greater cocaine-induced enhancement in locomotor activity are consistent with previous observations in several species that females are more sensitive to the behavioral effects of cocaine (Sell et al, 2000;Schindler and Carmona, 2002). It has been demonstrated that psychostimulant-induced ambulatory behavior and stereotypy are mediated by dopamine (DA) signaling in the nucleus accumbens (Sharp et al, 1987) and the striatum (Asher and Aghajanian, 1974). Thus, sex differences in the DA system in these areas may contribute to the observed effects.…”
Section: Discussionsupporting
confidence: 92%
“…It is likely, therefore, that hyper-responsive striatal dopamine transmission promotes the development of habits (see Faure et al, 2005), perhaps by easing the way in which information is processed through the ventral-to-dorsal striatal spiraling pathways (Haber et al, 2000). Interestingly, increased dopamine transmission in the dorsal striatum is associated with the expression of species-specific stereotyped behaviors (Asher and Aghajanian, 1974; Kelly et al, 1975; Creese and Iversen, 1975), which supports the notion that the dorsal striatal dopamine regulates automatic non-goal-directed behaviors. In addition, a recent study showed that acquisition of automized behavior is accompanied by changes in excitatory transmission that progresses from the dorsomedial to the dorsolateral striatum and, moreover, that adequate performance of this behavior was dopamine-dependent (Yin et al, 2009).…”
Section: Pathways Underlying the Flow Of Information From Ventral To supporting
confidence: 68%
“…The nigrostriatal pathway consists of dopaminergic cell bodies in the substantia nigra which innervates the caudate putamen. Enhanced dopaminergic neurotransmission in the caudate putamen following psychostimulant administration is associated with hyperactivity, especially an increase in stereotypic behaviors (Asher and Aghajanian 1974; Kuczenski et al 1991; Ushijima et al 1995). Of particular relevance to the present study, administration of CXCL12 into the substantia nigra has been shown to increase both contralateral turning and extracellular dopamine within the caudate putamen (Skrzydelski et al 2007).…”
mentioning
confidence: 99%