6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats

Asher, Irving M.; Aghajanian, George K.

doi:10.1016/0006-8993(74)90888-9

Cited by 110 publications

(18 citation statements)

References 25 publications

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“…Our results that females showed greater cocaine-induced enhancement in locomotor activity are consistent with previous observations in several species that females are more sensitive to the behavioral effects of cocaine (Sell et al, 2000;Schindler and Carmona, 2002). It has been demonstrated that psychostimulant-induced ambulatory behavior and stereotypy are mediated by dopamine (DA) signaling in the nucleus accumbens (Sharp et al, 1987) and the striatum (Asher and Aghajanian, 1974). Thus, sex differences in the DA system in these areas may contribute to the observed effects.…”

Section: Discussionsupporting

confidence: 92%

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig

Wang

Rasakham²,

Huang³

et al. 2011

J Pharmacol Exp Ther

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We examined whether sex differences in -opioid receptor (KOPR) pharmacology exist in guinea pigs, which are more similar to humans in the expression level and distribution of KOPR in the brain than rats and mice. The KOPR agonist trans-(Ϯ)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]-cyclohexyl)benzeneacetamide methanesulfonate (U50,488H) produced a dose-dependent increase in abnormal postures and immobility with more effects in males than females. Males also showed more U50,488H-induced antinociception in the paw pressure test than females. Pretreatment with the KOPR antagonist norbinaltorphimine blocked U50,488H-induced abnormal body postures and antinociception. In contrast, inhibition of cocaine-induced hyperambulation by U50,488H was more effective in females than males. Thus, sex differences in the effects of U50,488H are endpoint-dependent. We then examined whether sex differences in KOPR levels and KOPR-mediated G protein activation in brain regions may contribute to the observed differences using quantitative in vitro autora-

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Section: Discussionsupporting

confidence: 92%

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig

Wang

Rasakham²,

Huang³

et al. 2011

J Pharmacol Exp Ther

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“…It is likely, therefore, that hyper-responsive striatal dopamine transmission promotes the development of habits (see Faure et al, 2005), perhaps by easing the way in which information is processed through the ventral-to-dorsal striatal spiraling pathways (Haber et al, 2000). Interestingly, increased dopamine transmission in the dorsal striatum is associated with the expression of species-specific stereotyped behaviors (Asher and Aghajanian, 1974; Kelly et al, 1975; Creese and Iversen, 1975), which supports the notion that the dorsal striatal dopamine regulates automatic non-goal-directed behaviors. In addition, a recent study showed that acquisition of automized behavior is accompanied by changes in excitatory transmission that progresses from the dorsomedial to the dorsolateral striatum and, moreover, that adequate performance of this behavior was dopamine-dependent (Yin et al, 2009).…”

Section: Pathways Underlying the Flow Of Information From Ventral To supporting

confidence: 68%

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Pierce

Vanderschuren

2010

Neuroscience & Biobehavioral Reviews

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Cocaine addiction is a complex and multifaceted process encompassing a number of forms of behavioral plasticity. The process of acquiring and consuming drugs can be sufficiently risky and complicated that the casual drug user may choose not to act on every motivation to use drugs. The repetition of drug seeking and taking, however, often results in the gradual development of drug craving and compulsive drug seeking associated with addiction. Moreover, the complex sets of behaviors associated with drug addiction can become ingrained to such an extent that, when activated by drug-associated stimuli or exposure to the drug itself, the processes underlying drug seeking and taking are automatically engaged and very difficult to suppress. Here, we examine the hypothesis that aspects of cocaine seeking and taking become ingrained with repetition, thereby contributing to continued drug use despite a conscious desire to abstain. We also review emerging evidence indicating that neuronal circuits including the dorsolateral striatum play a particularly important role in the habitual aspects of drug seeking and taking.

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“…The nigrostriatal pathway consists of dopaminergic cell bodies in the substantia nigra which innervates the caudate putamen. Enhanced dopaminergic neurotransmission in the caudate putamen following psychostimulant administration is associated with hyperactivity, especially an increase in stereotypic behaviors (Asher and Aghajanian 1974; Kuczenski et al 1991; Ushijima et al 1995). Of particular relevance to the present study, administration of CXCL12 into the substantia nigra has been shown to increase both contralateral turning and extracellular dopamine within the caudate putamen (Skrzydelski et al 2007).…”

mentioning

confidence: 99%

Modulation of cocaine-induced activity by intracerebral administration of CXCL12

Trecki

Unterwald

2009

Neuroscience

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The role of chemokines in immune function is clearly established. Recent evidence suggests that these molecules also play an important role in the CNS as modulators of neuronal activity. The chemokine CXCL12 has been identified in several regions of the adult rat brain including the substantia nigra, ventral tegmental area and caudate putamen. CXCR4, a receptor activated by CXCL12, is expressed by dopaminergic neurons in the substantia nigra. The present study tested the effects of intracranial injections of CXCL12 on cocaine-induced locomotion and stereotypic activity in adult male Sprague Dawley rats. Results demonstrate that intracerebroventricular administration of CXCL12 (25 ng/4 μl) 15 minutes prior to cocaine (20 mg/kg IP) produced a significant potentiation of both ambulatory and stereotypic activity as compared to cocaine alone. The effects of CXCL12 were blocked by administration of the selective CXCR4 antagonist, AMD 3100. Administration of CXCL12 into specific brain regions was performed to further understand the site of action of CXCL12. Bilateral administration of CXCL12 (25 ng/0.5 μl) into the ventral tegmental area 15 minutes prior to cocaine (20 mg/kg IP) significantly potentiated cocaine-induced ambulatory activity, whereas microinjections of CXCL12 into the caudate putamen selectively increased stereotypy. Conversely, administration of CXCL12 into the lateral shell of the nucleus accumbens resulted in an inhibition of cocaine-stimulated ambulatory activity. No alterations in ambulatory or stereotypic activity were observed following CXCL12 administration into the core of the nucleus accumbens. These results demonstrate that CXCL12 can modulate the behavioral effects produced by cocaine in a brain region-specific manner. Keywords chemokine; psychostimulant; CXCR4; dopamine; mesolimbic; nigrostriatal Chemokines are defined as small (8-14 kDa) chemoattractant cytokines involved in a variety of developmental and pathological conditions. Recent reports propose that endogenous chemokines within the brain act in conjunction with neurotransmitters to modulate brain functions (Adler et al. 2005). The chemokines themselves have been hypothesized to act as Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Adler et al. 2005;Burbassi et al. 2008). NIH Public AccessCXCL12, formerly known as stromal cell derived factor one alpha (SDF-1α), is a CXC category chemokine secreted by bone marrow stromal cells as well as populations of neuronal and nonneuronal cells within the adult rat brain (Stumm et al. 2002). CXCL12 is involved in embryogenesis, cell migration an...

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6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats

Cited by 110 publications

References 25 publications

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Modulation of cocaine-induced activity by intracerebral administration of CXCL12

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6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: Effect on amphetamine-induced stereotyped behavior in rats

Cited by 110 publications

References 25 publications

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[35S]Thiotriphosphate) Binding in the Guinea Pig

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[35S]Thiotriphosphate) Binding in the Guinea Pig

Kicking the habit: The neural basis of ingrained behaviors in cocaine addiction

Modulation of cocaine-induced activity by intracerebral administration of CXCL12

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Product

Resources

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Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig

Sex Difference in κ-Opioid Receptor (KOPR)-Mediated Behaviors, Brain Region KOPR Level and KOPR-Mediated Guanosine 5′-O-(3-[³⁵S]Thiotriphosphate) Binding in the Guinea Pig