6-Deoxyclitoriacetal from Clitoria macrophylla

Antiinflammatory activity of rotenoids from Clitoria fairchildiana

“…The soluble fraction was concentrated and furnished a residue which was fractionated on silica gel using a CHCl 3 -MeOH gradient. Fractions containing rotenoids were further purified by exclusion chromatography to afford 6-deoxyclitoriacetal (1) (Lin et al, 1992), 11-deoxyclitoriacetal (2) (Mathias et al, 1998), clitoriacetal (3) (Taguchi et al, 1977), 9demethylclitoriacetal (4) (Silva et al, 1998) and stemonal (5) (Shiengthong et al, 1974).…”

“…The latter was reported as the major component and possessed remarkable antiinflammatory and antipyretic activities (Taguchi et al, 1977). Moreover, from its roots 6-deoxyclitoriacetal was isolated, which in vitro tests showed strong cytotoxic activity against lymphocytic leukaemia cells (Lin et al, 1992). To complete the investigation into the folklore uses of these plants, and the described biological activities, this work sets out to study these and related rotenoids using a vascular permeability assay as indicative of antiinflammatory properties.…”

Isoflavones and Rotenoids from the Leaves of Millettia brandisiana

“…9) Compound 7 also showed smooth muscle relaxant activity through a nonspecific mechanism by interference with intracellular calcium metabolism. 18) Two rotenoids, 6-deoxyclitoriacetal (7) and stemonal (9), were studied for anti-inflammatory activity.…”

“…3) In the present investigation, the ethyl acetate extract of the leaves yielded a new isoflavone, 4Ј-g,g-dimethylallyloxy-5,7,2Ј,5Ј-tetramethoxyisoflavone (1), as well as a synthetically known isoflavone, 7,4Ј-di-O-prenylgenistein (2), 4) three known isoflavones, eight known rotenoids, and a sterol. The structures of the known compounds were determined to be robustigenin (3), 5) toxicarol isoflavone (4), 6) viridiflorin (5), 7) sermundone (6), 8) 6-deoxyclitoriacetal (7), 9) 6a,12a-dehydrosermundone (8), 10,11) stemonal (9), 12) a-toxicarol (10), 13) 12a-hydroxy-atoxicarol (11), 14) 6a,12a-dehydro-a-toxicarol (12), 15) 6-hydroxy-6a,12a-dehydro-a-toxicarol (13), 16) and b-sitosterol (14) 17) by analysis of physical and spectroscopic evidence. In addition, the anti-inflammatory activity using ethyl phenylpropiolate-induced ear edema in rats of two pure compounds isolated was also studied.…”

Microtubulin Binding Sites as Target for Developing Anticancer Agents

“…The investigators found that T138067, in contrast to other known alkylating agents [224][225][226], significantly prevented the binding of colchicine to tubulin. This compound exhibited cytotoxicity against tumor cell lines that exhibit resistance to vinblastine, paclitaxel, doxorubicin, and actinomycin D. It showed equal effect against multi-drug resistance human tumor xenografts in athynic nude mice.…”