6‐Aryl‐Substituted Harmanium Derivatives as Light‐Up Probes for Fluorimetric DNA Detection and Staining of Eukaryotic Cells
Philipp Groß,
Renée S. Hoffmann,
Mareike Müller
et al.
Abstract:Nine 6‐aryl‐substituted harmanium derivatives were synthesized by Suzuki‐Miyaura coupling of 6‐bromoharmane with arylboronic acids and subsequent N2‐benzylation. Depending on the substitution pattern of the aryl group the emission maxima cover a range between λfl=445 and 529 nm with quantum yields of Φfl=<0.01–0.92. The interactions with duplex DNA were investigated by photometric and fluorimetric titrations as well as CD and LD spectroscopy. These ligands bind to DNA by intercalation with binding constants… Show more
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