6-Aminotriazolo[1,5-a]pyrimidines as precursors of 1,2,4-triazolo[5,1-b]purines

Abstract

Triazolo[5,1-b]purines are rare structural analogues of natural nucleosides and nucleobases purine series. At the same time, prominent representatives of azolopurines exhibit a broad spectrum of antiviral effect, activity against of rheumatoid arthritis, psoriasis, Alzheimer's, Parkinson's and etc. Despite the practical value azolo[5,1-b]purines extremely sparingly represented in the chemical literature, due to the complexity of their synthesis. We suggest a convenient way to synthesize triazolopurines with aminotriazolo[1,5-a]pyrimidines (2) as available starting compounds obtained in good yield by reduction of nitro derivatives (1).

Evaluation of different extraction techniques for the assay of anti - acetylcholinesterase activity of olive leaves (Olea europaea)

“…In recent years, a growing number of works aimed at the finding of new pharmaceutical substances based on secondary plant metabolites [3][4][5][6] for the treatment of various neurodegenerative diseases, including AD. One of these promising groups of plant metabolites are polyphe-nols, which are common components of plant raw materials and agricultural wastes.…”