6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei

Lai, Yongji; Zeng, Hong; He, Meijun; Qian, Huiqin; Wu, Zhengli; Luo, Zengwei; Xue, Yongbo; Yao, Guangmin; Zhang, Yonghui

doi:10.1016/j.fitote.2016.06.008

Cited by 25 publications

(11 citation statements)

References 25 publications

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“…Farrerol is a 2,3-dihydroflavonoid extracted from rhododendron. Farrerol is reported to exhibit various biological effects, such as anti-inflammation, antibiosis, and antioxidation (Lai et al, 2016;Wang et al, 2019a). Xin Ran et al reported that farrerol could protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in a mouse model.…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation resulting from various factors. Crohn’s disease (CD) and ulcerative colitis (UC) have been identified as the two major types of IBD. Currently, most of the drugs for IBD used commonly in the clinic have adverse reactions, and only a few drugs present long-lasting treatment effects. Moreover, issues of drug resistance and disease recurrence are frequent and difficult to resolve. Together, these issues cause difficulties in treating patients with IBD. Therefore, the development of novel therapeutic agents for the prevention and treatment of IBD is of significance. In this context, research on natural compounds exhibiting anti-inflammatory activity could be a novel approach to developing effective therapeutic strategies for IBD. Phytochemicals such as astragalus polysaccharide (APS), quercetin, limonin, ginsenoside Rd, luteolin, kaempferol, and icariin are reported to be effective in IBD treatment. In brief, natural compounds with anti-inflammatory activities are considered important candidate drugs for IBD treatment. The present review discusses the potential of certain natural compounds and their synthetic derivatives in the prevention and treatment of IBD.

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Section: Flavonoidsmentioning

confidence: 99%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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“…Farrerol is a natural compound that possesses broad pharmacological effects, such as antioxidative (Ci et al, ), anti‐inflammatory (Zhang, Yan, Zhuang, & Han, ), and antitumor activities (Liu et al, ). Previous study reported that farrerol exhibited strong neuroprotective effect, as evidenced by the inhibition of cell apoptosis in hydrogen peroxide‐ or amyloid β‐peptide‐induced SH‐SY5Y cells (Lai et al, ). However, the mechanism of the neuroprotective effect has not been fully investigated.…”

Section: Introductionmentioning

confidence: 99%

Farrerol attenuates MPP⁺‐induced inflammatory response by TLR4 signaling in a microglia cell line

Cui

Guo

You³

et al. 2019

Phytotherapy Research

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Farrerol was found to possess neuroprotective effect; however, the mechanism remains unknown. The aim of the present study was to explore the effect of farrerol on MPP + -induced inflammation in mouse microglial BV-2 cells and to elaborate the underlying mechanism. MTT assay was performed to measure the cell viability. The pro-inflammatory mediators and cytokines including interleukin (IL)-6, IL-1β, and tumor necrosis factor-α (TNF-α); inducible nitric oxide synthase; and cyclooxygenase 2 were measured. The expression of p-p65, p-IκBα, toll-like receptor 4 (TLR4), and myeloid differentiation primary response 88 were analyzed by western blot. We found that farrerol treatment improved cell viability in MPP + -induced BV-2 cells. MPP + -induced upregulation of IL-6, IL-1β, and TNF-α was inhibited by farrerol treatment. Farrerol treatment also attenuated MPP + -induced expression of inducible nitric oxide synthase and cyclooxygenase 2 as well as the activation of NF-κB in BV-2 cells. MPP + -induced TLR4 signaling was markedly diminished by farrerol treatment. Knockdown of TLR4 attenuated MPP + -induced inflammatory response in BV-2 cells. In conclusion, farrerol treatment attenuated MPP + -induced inflammatory response by inhibiting the TLR4 signaling pathway in BV-2 cells. The results indicated that farrerol could be used as a therapeutic agent for preventing or alleviating the neuroinflammation-related diseases, such as Parkinson's disease.

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“…Compound 2 was then characterized as a flavanone-type flavonoid bearing a prenyl at C-5′ and an upfield methyl at C-8. H-2 and H-3a showed a trans -arrangement as judged by their mutual coupling constant J = 12.5 Hz [ 24 , 32 , 33 ] characteristic of a trans -diaxial relationship between H-2 and H-3a. The phenyl group at C-2 was α-oriented following the comparison of the chemical shifts of carbons C-2, C-3, and C-1′ with those of the literature [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…The methyl group at C-8 in our derivatives might originate from the oxidation of the prenyl substituent in related analogues. Various flavonoids containing methyl groups in either position C-6 or C-8 have been isolated [ 33 ]. Thus, 2 and 3 are newly characterized and we proposed the trivial names cylindricines A ( 2 ) and B ( 3 ), respectively.…”

Section: Resultsmentioning

confidence: 99%

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

et al. 2021

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The local botanical Imperata cylindrica in Cameroon was investigated for its antibacterial potency. The methanol extract afforded a total of seven compounds, including five hitherto unreported compounds comprising three flavonoids (1–3) and two C-15 isoprenoid analogues (4 and 5) together with known derivatives (6 and 7). The novelty of the flavonoids was related to the presence of both methyl and prenyl groups. The potential origin of the methyl in the flavonoids is discussed, as well as the chemophenetic significance of our findings. Isolation was performed over repeated silica gel and Sephadex LH-20 column chromatography and the structures were elucidated by (NMR and MS). The crude methanol extract and isolated compounds showed considerable antibacterial potency against a panel of multi-drug resistant (MDR) bacterial strains. The best MIC values were obtained with compound (2) against S. aureus ATCC 25923 (32 µg/mL) and MRSA1 (16 µg/mL).

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6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei

Cited by 25 publications

References 25 publications

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Farrerol attenuates MPP⁺‐induced inflammatory response by TLR4 signaling in a microglia cell line

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

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6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortunei

Cited by 25 publications

References 25 publications

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Farrerol attenuates MPP+‐induced inflammatory response by TLR4 signaling in a microglia cell line

Prenylated Flavonoids and C-15 Isoprenoid Analogues with Antibacterial Properties from the Whole Plant of Imperata cylindrica (L.) Raeusch (Gramineae)

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Farrerol attenuates MPP⁺‐induced inflammatory response by TLR4 signaling in a microglia cell line