6,6′‐Bieckol inhibits adipocyte differentiation through downregulation of adipogenesis and lipogenesis in 3T3‐L1 cells

Abstract

These findings suggest that E. bicyclis suppressed differentiation of 3T3-L1 adipocyte through downregulation of adipogenesis and lipogenesis.

Indole Derivatives Isolated from Brown Alga Sargassum thunbergii Inhibit Adipogenesis through AMPK Activation in 3T3-L1 Preadipocytes

“…The differentiation of preadipocytes into mature adipocytes and the accumulation of fat play key roles in the pathogenesis of obesity [22]. Recently, many seaweed-derived bioactive compounds have been evaluated for their ability to inhibit adipogenesis [13,14,15]. Owing to their anti-obesity effect, these bioactive compounds may be excellent sources in the development of biomedical agents against obesity.…”

“…Seaweeds are known to provide an abundance of bioactive compounds with valuable biomedical and pharmaceutical potential [12]. Recently, the bioactive compounds of brown seaweeds were shown to offer potential in the management of obesity and obesity-related chronic diseases [13,14,15]. A wide range of extracts and bioactive compounds have been isolated from the brown alga Sargassum thunbergii , which possesses a variety of biological activities, including antioxidant activity, anti-inflammatory effects, neuroprotective effects, inhibitory effects on oxidative stress, and antibacterial effects [16,17,18,19].…”

Metabolic Disorder in Chronic Obstructive Pulmonary Disease (COPD) Patients: Towards a Personalized Approach Using Marine Drug Derivatives

“…Table 2 reports new drugs and drug derivatives obtained by different marine organisms proposed in anti-obesity treatment [62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94]. …”

Microwave hydrogravity pretreatment of Sargassum muticum before solvent extraction of antioxidant and antiobesity compounds

“…Other seaweed extracts were non‐toxic for 3 T3‐L1 cells: Ascophyllum nodosum extract (220 mg phlorotannin g –1 ) did not affect viability, ethanolic extracts of C. vulgaris did not affect the pre‐adipocyte viability up to 25 µg mL −1 but at 50–100 µg mL −1 exhibited slight cytotoxic effects . The viability in the presence of 6,6′‐bieckol, 6,8′‐bieckol, 8,8′‐bieckol, dieckol and phlorofucofuroeckol A at concentrations of 10–50 µg mL −1 was not affected . Sargassum thunbergii indole derivatives were non‐toxic and fucoidan from Fucus vesisulosus did not have toxicity on three T3‐L1 adipocytes, nor that from U. pinnatifida up to 100 µg mL −1.…”

“…32 The viability in the presence of 6,6 ′ -bieckol, 6,8 ′ -bieckol, 8,8 ′ -bieckol, dieckol and phlorofucofuroeckol A at concentrations of 10-50 μg mL −1 was not affected. 33 Sargassum thunbergii indole derivatives were non-toxic 34 and fucoidan from Fucus vesisulosus did not have toxicity on three T3-L1 adipocytes, 35 nor that from U. pinnatifida up to 100 μg mL −1. 36 The MHG-2 and ME-2 extracts were as active as caffeine, with 15% differentiation inhibition, but ME-1 showed more than 50% differentiation inhibition.…”