Abstract:These findings suggest that E. bicyclis suppressed differentiation of 3T3-L1 adipocyte through downregulation of adipogenesis and lipogenesis.
“…The differentiation of preadipocytes into mature adipocytes and the accumulation of fat play key roles in the pathogenesis of obesity [22]. Recently, many seaweed-derived bioactive compounds have been evaluated for their ability to inhibit adipogenesis [13,14,15]. Owing to their anti-obesity effect, these bioactive compounds may be excellent sources in the development of biomedical agents against obesity.…”
Section: Discussionmentioning
confidence: 99%
“…Seaweeds are known to provide an abundance of bioactive compounds with valuable biomedical and pharmaceutical potential [12]. Recently, the bioactive compounds of brown seaweeds were shown to offer potential in the management of obesity and obesity-related chronic diseases [13,14,15]. A wide range of extracts and bioactive compounds have been isolated from the brown alga Sargassum thunbergii , which possesses a variety of biological activities, including antioxidant activity, anti-inflammatory effects, neuroprotective effects, inhibitory effects on oxidative stress, and antibacterial effects [16,17,18,19].…”
Seaweed, a popular and abundant food ingredient mainly consumed in Asian countries, is a good source of bioactive compounds with anti-obesity effects. However, the anti-obesity effects of Sargassum thunbergii have not yet been established. In this study, we isolated six indole derivatives (STCs)—indole-2-carboxaldehyde (STC-1), indole-3-carboxaldehyde (STC-2), indole-4-carboxaldehyde (STC-3), indole-5-carboxaldehyde (STC-4), indole-6-carboxaldehyde (STC-5), and indole-7-carboxaldehyde (STC-6)—from S. thunbergii and evaluated their inhibitory effects on adipocyte differentiation in 3T3-L1 cells. We found that STC-1 and STC-5 resulted in non-toxic inhibition of the differentiation of 3T3-L1 adipocytes and thus selected these compounds for further study. STC-1 and STC-5 significantly inhibited lipid accumulation and downregulated the expression of peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) in a dose-dependent manner. The specific mechanism mediating the effects of STC-1 and STC-5 was shown to be AMP-activated protein kinase (AMPK) activation. Our results demonstrated the inhibitory effect of STC-1 and STC-5 on adipogenesis through the activation of the AMPK signal pathway. Together, these findings suggested that STC-1 and STC-5 may be effective candidates for the prevention of obesity or obesity-related diseases.
“…The differentiation of preadipocytes into mature adipocytes and the accumulation of fat play key roles in the pathogenesis of obesity [22]. Recently, many seaweed-derived bioactive compounds have been evaluated for their ability to inhibit adipogenesis [13,14,15]. Owing to their anti-obesity effect, these bioactive compounds may be excellent sources in the development of biomedical agents against obesity.…”
Section: Discussionmentioning
confidence: 99%
“…Seaweeds are known to provide an abundance of bioactive compounds with valuable biomedical and pharmaceutical potential [12]. Recently, the bioactive compounds of brown seaweeds were shown to offer potential in the management of obesity and obesity-related chronic diseases [13,14,15]. A wide range of extracts and bioactive compounds have been isolated from the brown alga Sargassum thunbergii , which possesses a variety of biological activities, including antioxidant activity, anti-inflammatory effects, neuroprotective effects, inhibitory effects on oxidative stress, and antibacterial effects [16,17,18,19].…”
Seaweed, a popular and abundant food ingredient mainly consumed in Asian countries, is a good source of bioactive compounds with anti-obesity effects. However, the anti-obesity effects of Sargassum thunbergii have not yet been established. In this study, we isolated six indole derivatives (STCs)—indole-2-carboxaldehyde (STC-1), indole-3-carboxaldehyde (STC-2), indole-4-carboxaldehyde (STC-3), indole-5-carboxaldehyde (STC-4), indole-6-carboxaldehyde (STC-5), and indole-7-carboxaldehyde (STC-6)—from S. thunbergii and evaluated their inhibitory effects on adipocyte differentiation in 3T3-L1 cells. We found that STC-1 and STC-5 resulted in non-toxic inhibition of the differentiation of 3T3-L1 adipocytes and thus selected these compounds for further study. STC-1 and STC-5 significantly inhibited lipid accumulation and downregulated the expression of peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) in a dose-dependent manner. The specific mechanism mediating the effects of STC-1 and STC-5 was shown to be AMP-activated protein kinase (AMPK) activation. Our results demonstrated the inhibitory effect of STC-1 and STC-5 on adipogenesis through the activation of the AMPK signal pathway. Together, these findings suggested that STC-1 and STC-5 may be effective candidates for the prevention of obesity or obesity-related diseases.
“…Table 2 reports new drugs and drug derivatives obtained by different marine organisms proposed in anti-obesity treatment [62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94]. …”
Metabolic disorder has been frequently observed in chronic obstructive pulmonary disease (COPD) patients. However, the exact correlation between obesity, which is a complex metabolic disorder, and COPD remains controversial. The current study summarizes a variety of drugs from marine sources that have anti-obesity effects and proposed potential mechanisms by which lung function can be modulated with the anti-obesity activity. Considering the similar mechanism, such as inflammation, shared between obesity and COPD, the study suggests that marine derivatives that act on the adipose tissues to reduce inflammation may provide beneficial therapeutic effects in COPD subjects with high body mass index (BMI).
“…Other seaweed extracts were non‐toxic for 3 T3‐L1 cells: Ascophyllum nodosum extract (220 mg phlorotannin g –1 ) did not affect viability, ethanolic extracts of C. vulgaris did not affect the pre‐adipocyte viability up to 25 µg mL −1 but at 50–100 µg mL −1 exhibited slight cytotoxic effects . The viability in the presence of 6,6′‐bieckol, 6,8′‐bieckol, 8,8′‐bieckol, dieckol and phlorofucofuroeckol A at concentrations of 10–50 µg mL −1 was not affected . Sargassum thunbergii indole derivatives were non‐toxic and fucoidan from Fucus vesisulosus did not have toxicity on three T3‐L1 adipocytes, nor that from U. pinnatifida up to 100 µg mL −1.…”
Section: Resultsmentioning
confidence: 99%
“…32 The viability in the presence of 6,6 ′ -bieckol, 6,8 ′ -bieckol, 8,8 ′ -bieckol, dieckol and phlorofucofuroeckol A at concentrations of 10-50 μg mL −1 was not affected. 33 Sargassum thunbergii indole derivatives were non-toxic 34 and fucoidan from Fucus vesisulosus did not have toxicity on three T3-L1 adipocytes, 35 nor that from U. pinnatifida up to 100 μg mL −1. 36 The MHG-2 and ME-2 extracts were as active as caffeine, with 15% differentiation inhibition, but ME-1 showed more than 50% differentiation inhibition.…”
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