6.11 N-Acylation Reactions of Amines

Copper-Catalyzed N-Benzoylation of Amines via Aerobic C–C Bond Cleavage

“…As a result, their storage and the process of the related N -benzoylation become complicated. Additionally, oxidative amidation of an aromatic aldehyde or benzylic alcohol with amines, N -chloroamines, azobenzenes, or even nitro benzenes is a type of strategy recently developed (Scheme b). , Recently, we reported a copper-catalyzed aerobic oxidative C–C bond cleavage of unstrained ketones with air and amines . In continuation of this work, we disclose herein a general approach for the N -benzoylation of amine via selective aerobic C–C bond cleavage of 1,2-diarylethan-1-one (Scheme c).…”

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

“…Many reviews of amide bond formation have already been written . This manuscript differentiates itself by evaluating coupling reagents used in the large-scale condensation of an acid and amine for the synthesis of drug candidates, while highlighting the benefits and drawbacks of each reagent on plant scale.…”

Photocatalytic Generation of Aminium Radical Cations for C–N Bond Formation

“…Given this context, it is perhaps unsurprising that nucleophilic, polar amination procedures such as reductive amination, nucleophilic substitution (S N 2 and S N Ar), , amide coupling, and transition-metal-mediated cross-coupling reactions (Buchwald–Hartwig, Ullmann–Goldberg, Chan–Lam, etc. ) − are the dominant methodologies for the construction of C–N bonds (Figure ).…”