5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment

Kumar, Naphatsorn; Rungseevijitprapa, Wandee; Narkkhong, Nual-Anong; Suttajit, Maitree; Chaiyasut, Chaiyavat

doi:10.1016/j.jep.2011.12.010

Cited by 80 publications

(67 citation statements)

References 27 publications

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“…Phyllanthus emblica L. is a potent inhibitor of 5 α -reductase, which promotes the growth of the hair of C57BL/6 mice [19]. The pine needle ( Pinus densiflora Sieb & Zucc.)…”

Section: Introductionmentioning

confidence: 99%

“…The roots and flowers of P. thunbergiana are used in traditional medicine because of their medicinal properties [21, 22], and a study of a murine model of hair loss demonstrates their antiandrogenic activity and proliferative effects on hair growth [19]. Similarly, the rhizome of the widely used member of the ginger family Zingiber officinale has been used for thousands of years to enhance the flavor and aroma of food.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

Gupta

Park

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner (p < 0.05), and 100 ppm of DA-5512 and 1 μM minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group (p < 0.05). MXD (3%) and DA-5512 (1%, 5%) significantly stimulated hair growth and increased the number and length of hair follicles (HFs) versus the controls (each p < 0.05). The groups treated with DA-5512 exhibited hair growth comparable to that induced by MXD. In clinical study, we detected a statistically significant increase in the efficacy of DA-5512 after 16 weeks compared with the groups treated with placebo or 3% MXD (p < 0.05). In conclusion, DA-5512 might promote hair growth and enhance hair health and can therefore be considered an effective option for treating hair loss.

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“…Phyllanthus emblica L. is a potent inhibitor of 5 α -reductase, which promotes the growth of the hair of C57BL/6 mice [19]. The pine needle ( Pinus densiflora Sieb & Zucc.)…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

Gupta

Park

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…In recent years, pharmacological studies have found various herbal ingredients that are anti-androgenic, inhibit 5αR, promote growth factor expression in hair follicles, regulate the endocrine system and enhance microcirculation (7,8). The dietary supplement L-carnitine induces hair growth in vitro (9), but it is not approved by the Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

Hair growth effect of traditional Chinese medicine BeauTop on androgenetic alopecia patients: A randomized double-blind placebo-controlled clinical trial

Lee¹,

Wei

Yu³

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the treatment effects of BeauTop in alopecia by observing its effectiveness in improving androgenetic alopecia. Hair growth was observed using a dermatoscope and clinical photos, and was scored by three dermatologists. Dermatologists evaluated and selected suitable participants for this study using the Norwood scale or Ludwig scale. A total of 40 participants with androgenetic alopecia were recruited in this study, and 32 participants completed the 6-month trial. The results revealed that in the BeauTop treatment group, 9/17 participants (52.9%) showed increased hair growth. Changes in hair growth were as follows: No change, 47.1% patients; minimally improved, 5.9% patients; moderately improved, 29.4% patients; and significantly improved, 17.6% patients. In the placebo group, 2/15 participants (13%) showed increased hair growth. A Chi-square test was performed and attained a value of 0.01

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“…Indeed, a combination of 5α-reductase inhibitors and hair growth promoters has been shown to improve AGA. 11,12) Alopecia may be treated topically and/or orally and by hair transplantation. However, hair transplantation is very expensive, oral medicines show hepatotoxicity, and topical medicines are not clearly effective in improving hair growth.…”

mentioning

confidence: 99%

“…Several natural compounds have been reported to have hair growth-promoting properties. [13][14][15][16] Bee venom is an oriental medicine that has recently been developed to relieve pain and to treat diseases such as rheumatoid arthritis, 17) Parkinson's disease, 18) cancer, 19,20) asthma, 21) and inflammatory disease. 22) Bee venom contains many active peptides such as melittin, apamin, mast cell degranulating peptide, and adolapin, as well as a variety of proteins and amines including phospholipase A2, hyaluronidase, histamine, dopamine, and norepinephrine.…”

mentioning

confidence: 99%

Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression

Park

Erdogan

Hwang

et al. 2016

Biological & Pharmaceutical Bulletin

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Alopecia is an important issue that can occur in people of all ages. Recent studies show that bee venom can be used to treat certain diseases including rheumatoid arthritis, neuralgia, and multiple sclerosis. In this study, we investigated the preventive effect of bee venom on alopecia, which was measured by applying bee venom (0.001, 0.005, 0.01%) or minoxidil (2%) as a positive control to the dorsal skin of female C57BL/6 mice for 19 d. Growth factors responsible for hair growth were analyzed by quantitative real-time PCR and Western blot analysis using mice skins and human dermal papilla cells (hDPCs). Bee venom promoted hair growth and inhibited transition from the anagen to catagen phase. In both anagen phase mice and dexamethasone-induced catagen phase mice, hair growth was increased dose dependently compared with controls. Bee venom inhibited the expression of SRD5A2, which encodes a type II 5α-reductase that plays a major role in the conversion of testosterone into dihydrotestosterone. Moreover, bee venom stimulated proliferation of hDPCs and several growth factors (insulin-like growth factor 1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)2 and 7) in bee venom-treated hDPCs dose dependently compared with the control group. In conclusion, bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter.

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5α-reductase inhibition and hair growth promotion of some Thai plants traditionally used for hair treatment

Cited by 80 publications

References 27 publications

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA‐5512 Effectively Stimulates Hair Growth and Promotes Hair Health

Hair growth effect of traditional Chinese medicine BeauTop on androgenetic alopecia patients: A randomized double-blind placebo-controlled clinical trial

Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression

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