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Basavaiah, K.; Nagegowda, P.; Somashekar, B. C.; Ramakrishna, V.

doi:10.2306/scienceasia1513-1874.2006.32.403

Cited by 28 publications

(15 citation statements)

References 3 publications

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“…A number of oxidisable pharmaceutical substances have earlier been assayed using cerium (IV) sulphate by several workers [32][33][34][35][36][37][38][39][40][41][42][43][44][45] based on several reaction schemes. The present methods entail adding a known excess of cerium (IV) sulphate to SMT in acid medium followed by the determination of unreacted oxidant by two reaction schemes involving the use of ferroin, and iron (II) and thiocyanate as reagents.…”

Section: Resultsmentioning

confidence: 99%

Cerimetric determination of simvastatin in pharmaceuticals based on redox and complex formation reactions

Basavaiah

Devi

2008

Eclet. Quim.

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Two sensitive spectrophotometric methods are described for the determination of simvastatin (SMT) in bulk drug and in tablets. The methods are based on the oxidation of SMT by a measured excess of cerium (IV) in acid medium followed by determination of unreacted oxidant by two different reaction schemes. In one procedure (method A), the residual cerium (IV) is reacted with a fixed concentration of ferroin and the increase in absorbance is measured at 510 nm. The second approach (method B) involves thereduction of the unreacted cerium (IV) with a fixed quantity of iron (II), and the resulting iron (III) is complexed with thiocyanate and the absorbance measured at 470 nm. In both methods, the amount of cerium (IV) reacted corresponds to SMT concentration. The experimental conditions for both methods were optimized. In method A, the absorbance is found to increase linearly with SMT concentration (r = 0.9995) whereas in method B, the same decreased (r = -0.9943). The systems obey Beer’s law for 0.6-7.5 and 0.5-5.0 μg mL-1 for method A and method B, respectively. The calculated molar absorptivity values are 2.7 X 104 and 1.06 X 105 Lmol-1 cm-1, respectively; and the corresponding sandel sensitivity values are 0.0153 and 0.0039μg cm-2, respectively. The limit of detection (LOD) and quantification (LOQ) are reported for both methods. Intra-day and inter-day precision, and accuracy of the methods were established as per the current ICH guidelines. The methods were successfully applied to the determination of SMT in tablets and the results were statistically compared with those of the reference method by applying the Student’s t-test and F-test. No interference was observed from the common excipients added to tablets. The accuracy and validity of the methods were further ascertained by performing recovery experiments via standard addition procedure.

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Section: Resultsmentioning

confidence: 99%

Cerimetric determination of simvastatin in pharmaceuticals based on redox and complex formation reactions

Basavaiah

Devi

2008

Eclet. Quim.

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“…Various spectrophotometric [1][2][3][4][5][6] methods, titrimetric and spectrophotometric methods [7,8] ,…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

A Simple Spectrophotometric Assay of Lamivudine in Pharmaceutical Formulations

Reddy¹

2017

WJPR

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A simple, sensitive and accurate spectrophotometric method has been developed for the estimation of lamivudine in bulk and pharmaceutical dosage forms. The amino group in lamivudine is diazotised with sodium nitrite and hydrochloric acid at 0 o C temperature. After diazotisation, the diazonium salt is coupled with resorcinol. The orange red coloured chromogen formed in the method is stable for more than 24 hours. The orange red coloured chromogen is measured at the wavelength of maximum absorbance 460 nm against the reagent blank.The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed.

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“…Most of them imply optical-based methods, namely spectrophotometric [5][6][7][8][9][10][11][12][13][14][15][16][17], fluorimetric [18][19][20][21][22], and turbidimetric [23] procedures that regard several chemical transformations of CPZ. High Performance Liquid Chromatography (HPLC) [24][25][26][27][28][29][30][31][32][33] electrophoresis [34] voltammetric [11,[35][36][37],coloumetric [38], polarographic [39] and spectroelectrochemical [12] procedures have been reported as well.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic sensors of molecularly-imprinted polymers for chlorpromazine determination

Moreira¹,

Sales²

2011

Materials Science and Engineering: C

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A new man-tailored biomimetic sensor for Chlorpromazine host-guest interactions and potentiometric transduction is presented. The artificial host was imprinted within methacrylic acid, 2-vinyl pyridine and 2-acrylamido-2-methyl-1-propanesulfonic acid based polymers. Molecularly imprinted particles were dispersed in 2-nitrophenyloctyl ether and entrapped in a poly(vinyl chloride) matrix. Slopes and detection limits ranged 51-67 mV/decade and 0.46-3.9 μg/mL, respectively, in steady state conditions. Sensors were independent from the pH of test solutions within 2.0-5.5. Good selectivity was observed towards oxytetracycline, doxytetracycline, ciprofloxacin, enrofloxacin, nalidixic acid, sulfadiazine, trimethoprim, glycine, hydroxylamine, cysteine and creatinine. Analytical features in flowing media were evaluated on a double-channel manifold, with a carrier solution of 5.0 × 10 −2 mol/L phosphate buffer. Near-Nernstian response was observed over the concentration range 1.0 × 10 −4 to 1.0 × 10 −2 mol/L. Average slopes were about 48 mV/decade. The sensors were successfully applied to field monitoring of CPZ in fish samples, offering the advantages of simplicity, accuracy, automation feasibility and applicability to complex samples.

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Cited by 28 publications

References 3 publications

Cerimetric determination of simvastatin in pharmaceuticals based on redox and complex formation reactions

Cerimetric determination of simvastatin in pharmaceuticals based on redox and complex formation reactions

A Simple Spectrophotometric Assay of Lamivudine in Pharmaceutical Formulations

Biomimetic sensors of molecularly-imprinted polymers for chlorpromazine determination

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