5PSQ-058 Comparative effectiveness of regorafenib versus trifluridine/tipiracil in metastatic colorectal cancer

Abstract

BackgroundRegorafenib and trifluridine/tipiracil (TAS-102) are indicated in metastatic colorectal cancer (mCRC) refractary to standard therapies. Both have been approved after being compared to placebo, so comparative studies with other therapies are needed.PurposeTo compare effectiveness and safety of regorafenib and TAS-102 in patients with advanced mCRC in real clinical practice.Material and methodsA retrospective observational study including all patients with mCRC who started treatment with regorafenib or TAS-102 between February 2013 and May 2017 was carried out.The following variables were collected: sex, KRAS-mutation, age and Eastern Cooperative Oncology Group scale (ECOG) at the beginning of treatment and previous lines. Qualitative and quantitative variables between groups were compared using chi2 and t-student tests, respectively.Median progression-free survival (PFS) and overall survival (OS) were recorded to evaluate effectiveness. Differences in survival were evaluated with the logrank test.Adverse effects (AEs) classified according to the Common Toxicity Criteria v4.0 and dose reductions were recorded to measure safety.Statistical analysis was carried out using Stata® 14.ResultsThroughout the period of the study 31 patients (41% males, median age 60.7 years, 77% ECOG 1, median previous lines 3.3) started treatment with regorafenib or TAS-102 (10 and 21, respectively). Both groups were comparable in the variables above described.The median PFS and OS in the regorafenib group were 1.77 (0.13–4.36) and 7 (0.03–13.97) months, while in the TAS-102 group these were 2.07 (1.38–3.15) and 7 (5.09–8.91) months. Differences in PFS (p=0.483) and OS (p=0.850) were not statistically significant.The median number of AEs per patient was 4.70 and 2.71 with regorafenib and TAS-102, respectively. Most of them were grade (G) 1–2. The most frequent AEs related to regorafenib were asthaenia (70%, n=7), diarrhoea, hand-foot syndrome, mucositis and hyporexia (30%, n=3), whereas the most common AEs with TAS-102 were asthaenia (42%, n=9), neutropaenia (38%, n=8) and nausea (33%, n=7). Dose reductions were necessary in three patients treated with regorafenib due to infections and asthaenia G3 and in four patients with TAS-102 due to neutropenia G2 (n=2), G3 (n=1) and G4 (n=1).ConclusionIn our study, regorafenib and TAS-102 have similar, modest effectiveness. Differences in toxicity may be decisive in the choice of either treatment.No conflict of interest

Interaction of Some Amino-Nitrile Derivatives with Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) Using a Theoretical Model

“…In addition, a study showed the beneficial effect produced by regorafenib and fruquintinib drugs (VEGF-1, VEGF-2, VEGF-3 inhibitors) 26 27 in patients with metastatic colorectal cancer 28 . All these studies show that several drugs have been used as VEGF-R1, VEGF-R2, and VEGF-R3 inhibitors for the treatment of different cancer cells; however, some anticancer drugs can produce secondary effects, such as hypertension 29 30 31 , diarrhea 32 , and thromboembolic events 33 . In the search for therapeutic alternatives, several compounds have been prepared as anticancer agents; for example, anthranilic acid amides have been synthesized as VEGF-R2 and VEGF-R3 inhibitors using an angiogenesis model 34 .…”