5HT1A and 5HT1B receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats

Involvement of 5-HT1A in the anxiolytic-like effect of dichloromethane fraction of Pimenta pseudocaryophyllus

“…However, DF anxiolytic-like effect was blocked by pre-treatment with . In spite of conflicting reports on the specificity of NAN-190 (Petkov et al, 1995;Foong et al, in press;Huo et al, 2010), this drug is commonly used in the literature as a 5-HT 1A antangonist (Solati et al, 2011;Gonç alves et al, in press). In addition, the 5-HT 1A antagonism of NAN-190 at the dose used was confirmed by the reduction in buspirone (a 5-HT 1A partial agonist) effect, suggesting an involvement of this receptor in DF anxiolytic-like effects.…”

Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain

“…Moreover, intra-hippocampal injection of 8-OH-DPAT had anxiogenic effects in the inhibitory avoidance test (Dos Santos et al, 2008). Similarly, intra-medial PFC administration of 8-OH-DPAT increased anxiety in the EPM test (Solati et al, 2011). Thus, the reduced amount of 5-HT1ARs observed in the brain of the experimental mothers, could act in a way inverse from that of the administration of the 5-HT1AR agonist, i.e.…”

Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects ofScrophularia striataextract in rats

“…The inner cannula was left in place for an additional 60 s to allow diffusion of the solution and to reduce the possibility of reflux. Intra-CV injection was made 5 min before testing (Solati et al, 2011).…”

“…Five minutes following their respective drug treatment, rats were placed individually at the center of the EPM, facing one of the open arms. The observer measured (1) (Solati et al, 2010(Solati et al, , 2011.…”