599 ALLELES AND GENOTYPES OF IL-18 AND TNF-α PROMOTER POLYMORPHISMS ARE ASSOCIATED WITH HIGHER RISKOF HEPATOCELLULAR CARCINOMA (HCC) IN BRAZILIAN POPULATION

Teixeira, Andreza Corrêa; Mendes-Júnior, C.T.; Souza, Fernanda Fernandes; Cantão, Cássio Alfred Brattig; Ferreira, Suzete Cleusa; Deghaid, N.H.S.; Castelli, Erick C.; Mente, Ênio David; Sankarankutty, Ajith Kumar; Zucoloto, Sérgio; Elias, John J.; Muglia, Valdair Francisco; Castro-Silva, O; Ea, Donadi; Martinelli, Axel

doi:10.1016/s0168-8278(10)60601-0

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2013

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“…We evaluated, in a Brazilian cohort, the association of alleles and genotypes of the 14bp insertion/deletion polymorphism of the HLA-G gene, and alleles and genotypes of polymorphisms of genes IL-18 (-607 C/A; rs1946518 and -137 C/G; rs187238), IFN-γ (+874 A/T; rs62559044) and TNF-α (-238 A/G; rs361525 and -308 A/G; rs1800629) with susceptibility to HCC and with the type of tumor presentation (infiltrative diffuse, multinodular and uninodular), with nodule size (>10 cm, 5-10 cm and <5 cm), with the Milan criteria (fulfills or does not fulfill), the evaluation of metastasis (present or absent), and the histological classification of the tumor (Edmondson-Steiner Classification) [18,19,20,21].…”

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confidence: 99%