Abstract:BackgroundDespite rigorous multimodal therapy, recurrence is common among high-risk neuroblastoma patients. Neuroblastoma is a poorly immunogenic tumor with low tumor mutational burden (TMB). Currently, immunotherapy with immune checkpoint inhibitors (ICIs) are not approved for neuroblastoma. Novel strategies to sensitize neuroblastoma to ICIs are urgently needed. We have induced mismatch repair (MMR) deficiency in mouse neuro-2a tumors and show that these tumors become highly immunogenic and responsive to ant… Show more
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