586 LY171883 activity in the treatment of asthma

Kemp, James; Platts-Mills, Thomas A.E.; Tinkelman, David G.; Woehler, Thomas; Enas, Greg G.; Ac, Dowell

doi:10.1016/0091-6749(88)90820-2

Cited by 1 publication

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“…LY171883, an orally active LTD 4 -LTE4 antagonist, has been shown to be only marginally effective in improving symptom scores in patients with asthma discontinued from theophylline treatment. 20 L-649,923 is a competitive antagonist of LTD 4 and, to a lesser extent, LTC 4 . 21 Oral doses antagonize LTD 4 -induced bronchoconstriction in normal human subjects 22 and protect against bronchoconstriction caused by antigen challenge in asthmatic subjects.…”

Section: Otolaryngology-head and Nock Surgerymentioning

confidence: 97%

The effect of a leukotriene antagonist on the early response to antigen

Kagey‐Sobotka

Lichtenstein

et al. 1990

Otolaryngol.--head neck surg.

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The sulfidopeptide leukotrienes (LT) C4, D4, and E4 increase in nasal secretions during the nasal response to antigen challenge, and nasal challenge with LTD4 induces nasal congestion. To further assess the role of leukotrienes, we administered an oral LTD4 antagonist, L-649,923, to 12 patients who had nasal allergy to grass and ragweed pollen, in a double-blind, placebo-controlled, crossover study. Patients were challenged intranasally with increasing doses of pollen on each of 2 days, and the recovered nasal lavage fluids were assayed for histamine, TAME-esterase activity, and immunoreactive LTC4/D4/E4. The patients graded runny nose, congestion, and throat irritation, and sneezes were counted. Significant (p less than 0.01) increases in all parameters were found when comparing antigen challenge with diluent challenge, but no differences were seen among the treatment groups. Thus, oral L-649,923 was not effective in blocking the symptoms of the early nasal allergic response.

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Section: Otolaryngology-head and Nock Surgerymentioning

confidence: 97%