581 Une nouvelle ciclosporine A 1 % et 2 % : toxicité, tolérance et observance

Borel, André; Albertini, Enrico; Bonnin, N.; Bontemps, C.; Boyer, Alexandre; Chopineau, J.; Chiambaretta, F.

doi:10.1016/s0181-5512(09)73705-2

Cited by 2 publications

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“…Intolerance has been addressed in previous studies on topical CSA because it can hinder its effectiveness. 3,23–25 Jeng and Holsclaw 4 reported the absence of intolerance in their CSA-treated group. Conversely, other authors noted moderate to severe intolerance to CSA in 7% to 25% of patients.…”

Section: Discussionmentioning

confidence: 99%

Corticosteroids Versus Cyclosporine for Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: A Prospective Randomized Double-Blind Study

Gouider

Khallouli

Maalej

et al. 2020

Cornea

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Purpose: To compare efficiency and tolerance between topical 0.5% cyclosporine A (CSA) and fluorometholone (FML) for subepithelial infiltrates (SEI) complicating epidemic keratoconjunctivitis. Methods:We conducted a prospective double-blind randomized study involving 72 eyes with SEI. Thirty-eight eyes were treated with topical FML (FML group) and 34 eyes with CSA 0.5% eye drops (CSA group). Treatment was considered successful in case of SEI reduction and visual acuity improvement. Tolerance was evaluated by Schirmer test value, burning on eye drops instillation, and conjunctival injection.Results: Baseline characteristics of both groups were similar (P . 0.05). After 3 months of the regimen, resolution of SEI was 3 times more observed in the FML group than that in the CSA group (P = 0.026). After 6 months, resolution of SEI was observed in 70% of the FML group and in 47% of the CSA group (P = 0.068). The recurrence of SEI was almost twice higher in the FML group than that in the CSA group (16% vs. 9%). FML was better tolerated during the first 3 months: a higher Schirmer test value (P = 0.0003), less burning on instillation (P = 0.242), and less conjunctival injection (P = 0.003). For the rest of the follow-up period, the 2 groups were comparable in tolerance. No ocular hypertension was noted.Conclusions: Epidemic keratoconjunctivitis can evolve favorably under both FML and CSA. The effect of FML is faster and CSA is more durable with fewer recurrences. Both are safe therapeutic options for long-term control of SEI.

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Section: Discussionmentioning

confidence: 99%

Corticosteroids Versus Cyclosporine for Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: A Prospective Randomized Double-Blind Study

Gouider

Khallouli

Maalej

et al. 2020

Cornea

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Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts

Lallemand

Schmitt

Bourges

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

140

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Local ocular delivery of cyclosporine A (CsA) is the preferred method for CsA delivery as a treatment for ocular inflammatory diseases such as uveitis, corneal healing, vernal keratoconjunctivitis and dry eye disease. However, due to the large molecular weight and hydrophobic nature of CsA and the natural protective mechanisms of the eye, achieving therapeutic levels of CsA in ocular tissues can be difficult. This review gives a comprehensive overview of the current products available to clinicians as well as emerging drug delivery solutions that have been developed at both the academic and industry levels.

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581 Une nouvelle ciclosporine A 1 % et 2 % : toxicité, tolérance et observance

Cited by 2 publications

References 0 publications

Corticosteroids Versus Cyclosporine for Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: A Prospective Randomized Double-Blind Study

Corticosteroids Versus Cyclosporine for Subepithelial Infiltrates Secondary to Epidemic Keratoconjunctivitis: A Prospective Randomized Double-Blind Study

Cyclosporine A delivery to the eye: A comprehensive review of academic and industrial efforts

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