562-P: Influence of Glycemic Control and Variability on Diabetic Retinopathy in Type 1 Diabetes Patients on Continuous Subcutaneous Insulin Infusion Therapy

Abstract

Introduction: There is scarce evidence demonstrating a relationship between glycemic control or glycemic variability with diabetic retinopathy (DR). Objectives: We aimed to determine the prevalence of DR and its association with time in range (TIR), and other association factors. Methods: We performed a retrospective observational study with 130 T1DM patients on continuous subcutaneous insulin infusion (CSII). Data of the three previous months were downloaded and analyzed. Results: Mean age was 37±13 years-old. 51.5% were female. Mean BMI was 24.8±4.0 Kg/m2. Duration of T1DM was 21±10 years. The mean HbA1c was 7.1±0.8%; before CSII 7.4±1.0%. Mean LDL-c was 100±26 mg/dL. The prevalence of DR was 20.8% (95%CI: 14.7 - 28.5); 19.2% non-proliferative DR and 1.5% proliferative DR. Most glycemic control and variability parameters were significantly higher in the DR+ group (Table 1). After applying the stepwise logistic regression model (p<0.001, R2 0.561), the association factors for developing DR were: LDL-c, ExpB 0.97 (95%CI 0.95-0.99); duration of DM, ExpB 1.26 (95%CI 1.12-1.41); and HbA1c before CSII, ExpB 2.24 (95%CI 1.17-4.31). Conclusions: Lower TIR and higher time in hyperglycemia were observed in patients with DR. LDL-c levels, long duration of DM and higher HbA1c before CSII were independent association factors for the development of DR. Disclosure E. Lecumberri: None. N. Bengoa: None. M. Fernández Argüeso: None. L. Nattero Chávez: None.