56. Radiographic contrast media (RCM) infusions: Measurement of mediators and correlation with clinical parameters

Šimon, Róbert; Schätz, Michael; Stevenson, Donald D.; Curry, Nancy S.; Yamamoto, Fujio; Plow, EF; Ring, Hans Christian; Arroyave, Carlos M.

doi:10.1016/0091-6749(78)90295-6

Cited by 27 publications

(29 citation statements)

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“…For further conditions see ANSELL et al (1980) routine. Similar studies to that of SEIDEL et al (1974) were performed several years later by a series of authors all over the world: SIMON et al (1979), COGEN et al (1979, REIMANN et al (1985), GMEINWIESER et al (1985), ROBERTSON et al (1985), REISER et al (1986), HERD et al (1988) and TSCHAKERT (1989). These studies were completed by the measurement of histamine and N~-methylhistamine in urine (KALINER et al 1984;KEYZER et al 1984;BIELORY and KALINER 1985).…”

Section: Contrast Media During Operationsmentioning

confidence: 62%

Histamine in Anaesthesia and Surgery: Causality Analysis

Lorenz¹,

Dietz²,

Ennis³

et al. 1991

Histamine and Histamine Antagonists

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Section: Contrast Media During Operationsmentioning

confidence: 62%

Histamine in Anaesthesia and Surgery: Causality Analysis

Lorenz¹,

Dietz²,

Ennis³

et al. 1991

Histamine and Histamine Antagonists

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“…The anaphylactoid reactions observed following administration of RCM range from dypsnea, urticaria, puritus, angioedema, to hypotension or shock [49]. Both in vivo and in vitro experiments provide strong evidence that histamine release from mast cells and basophils plays a role in these adverse reactions [50][51][52][53][54][55]. Reports have suggested that RCM activate mast cells through complement activation by production of anaphylatoxins [53,54] or via direct activation of the cells via an as yet unknown mechanism [46,49].…”

Section: Radiographic Contrast Mediamentioning

confidence: 99%

Clinical consequences of mast cell heterogeneity

Forsythe¹,

Ennis²

2000

Inflammation Research

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The heterogeneous morphological, biochemical and functional characteristics of mast cells from different species and from different tissue sites in the same species have been described for over 30 years. Far from being mere histochemical or pharmacological curiosities these differences have far reaching implications for therapeutic practice. This review concentrates on two important areas affected by mast cell heterogeneity, those of adverse reactions to therapeutic agents and the efficacy of anti-allergy therapy. In vitro studies of preformed and de novo synthesised mediator release have demonstrated a wide variability in the response of basophils and isolated mast cells to anti-allergy drugs and therapeutic agents such as radiographic contrast media, general anaesthetics, opioids and muscle relaxants. This heterogeneity is not limited to the mast cell's tissue of origin as there is also variability in the response of basophils and mast cells from different donors to the same drug or agent. These data have considerable clinical implications for the study of adverse drug reactions and the design of novel anti-allergic drugs.

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“…The lack of in vitro activation of skin mast cells by the RCM we tested suggests that the mechanism of cutaneous reac tions to RCM involves, besides direct activation of baso phils, complement activation and anaphylatoxin formation [77,78,83] that may trigger skin mast cells in vivo.…”

Section: Radio Contrast Mediamentioning

confidence: 99%

“…RCM with lower osmolality have been developed [77,78] and these preparations cause a lower incidence of reac tions than the older hyperosmolar agents [77,79,81], The overall incidence of adverse reactions to RCM varies from 4.6 to 8.5% with fatalities occurring in 0.002-0.009% of all procedures [78], Anaphylactoid reactions range from urti caria, angioedema. pruritus, dyspnea, to hypotension or shock [82] and account for 20-30% of all reactions to RCM [78] In vivo [83][84][85] and in vitro [86 88] studies suggest that histamine release from basophils and mast cells plays a role in the pathogenesis of these adverse reactions. It has been suggested that RCM activate basophils and mast cells through complement activation by the production o f anaphylatoxins [77,80,84] as a consequence of hyperosmolal ity [86,87], or by inducing mediator release through as yet unidentified metabolic pathways [77,82],…”

Section: Radio Contrast Mediamentioning

confidence: 99%

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

Genovese

Stellato

Marsella

et al. 1996

Int Arch Allergy Immunol

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General anesthetics and radiocontrast media (RCM) can cause anaphylactic or anaphylactoid reactions. These are usually underdiagnosed and underreported, but their incidence is apparently rising. Their pathogenesis is complex and not completely understood, but the release of vasoactive mediators from basophils and mast cells plays a central role. The recent development of in vitro techniques to study the release of preformed (histamine and tryptase) and de novo synthesized mediators (PGD₂, LTC₄, and PAF) from purified basophils and mast cells has made it possible to quantify the mediator-releasing activity of anesthetics such as muscle relaxants, general anesthetics, opioids, and benzodiazepines and RCM on human basophils and mast cells isolated from lung, skin and heart tissues. The majority of general anesthetics and RCM tested induced only the release of preformed mediators (histamine and tryptase), not of the de novo synthesized eicosanoids. There was wide variability in the response of basophils and mast cells from different donors to the same drug or RCM, presumably due to the releasability parameter. Hyperosmolality is probably not the only factor responsible for basophil and mast cell activation by RCM. The in vitro release of histamine induced by anesthetic drugs and RCM was correlated with the release of tryptase. Given the longer half-life of tryptase than histamine in plasma, measurements of plasma tryptase may become a useful diagnostic tool for identifying adverse reactions to anesthetics and RCM.

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56. Radiographic contrast media (RCM) infusions: Measurement of mediators and correlation with clinical parameters

Cited by 27 publications

References 0 publications

Histamine in Anaesthesia and Surgery: Causality Analysis

Histamine in Anaesthesia and Surgery: Causality Analysis

Clinical consequences of mast cell heterogeneity

Role of Mast Cells, Basophils and Their Mediators in Adverse Reactions to General Anesthetics and Radiocontrast Media

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