56-P: Prediction of flow cytometry and AHG-CDC crossmatch results by multiplex bead array MFI

Schmitz, John L.; Collins, Dana; Crawford, John; Petraroia, Rosanne; Crawford, Tricia; Furmage, Nicole; Jiménez, Héctor Miguel Aviña

doi:10.1016/j.humimm.2009.09.089

Cited by 1 publication

(1 citation statement)

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“…We believe that this would be true, considering observations published by other authors. [13][14][15][16] Our estimation of HSP chances for HLA class I antibodies to find a suitable renal graft from a deceased donor was that 37.5%, 65% and 72.5 % of them would find a donor within one, two, and three years after inclusion in the program, respectively. It should be noticed that such figures are derived from estimations based on the anti-HLA-A and -B evaluation, but not anti-HLA-C antibodies.…”

Section: Discussionmentioning

confidence: 99%

Proposal for a program to enhance renal transplantation opportunity for highly sensitized patients

Campos

Doxiadis

Temin

et al. 2010

bjt

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Purpose: The accumulation of highly sensitized patients (HSP) on renal transplant waiting lists is a universal problem and finding donors for them represents a major challenge for organ distribution organizations. The purpose of this report is to describe a possible Brazilian version of the Eurotransplant Acceptable Mismatch program and the results of a study performed to test its efficiency. Method: The acceptable mismatches were defined with the single antigen beads Luminex assay, each test being individually interpreted with aid of the HLAMatchmaker algorithm. Negative-crossmatch prediction was validated in 86 T cell crossmatches using complement dependent cytotoxicity with anti-human globulin. Results: The estimation of the chances of 40 HSP to find a donor through the program showed that about 70% of them would be offered an ABO compatible, zero HLA-DR mismatched, T and B cell crossmatch negative graft within a two-year period after joining the program. On the other hand, for about 30% of the patients, the chances to find a suitable donor would be minimal, even after three or five years. Conclusions: We estimated that around 70% of the HSP would clearly benefit from the algorithm proposed in this study. On the other hand, those patients for whom it would be highly improbable to find a compatible donor would be primary candidates for desensitization/antibody reduction protocols. Therefore, we concluded that the information regarding the transplantability of each HSP provided by the algorithm herein described is a powerful tool for a proper management of highly sensitized patients in regional, national and international organizations as to deceased donor kidneys distribution.

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Section: Discussionmentioning

confidence: 99%