556 Role of Il-10-Producing Regulatory B Cells in the Pathogenesis of Chronic HBV Infection

Das, Abhishek; Ellis, G.; Peppa, Dimitra; Brunetta, M; Blair, Paul A.; Mauri, Claudia; Maini, Mala K.

doi:10.1016/s0168-8278(08)60558-9

Cited by 2 publications

(3 citation statements)

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“…In order to study IL-10-producing B cells expression in HBV-MN disease, we examined the frequency of these cells and found that the percentages of CD5 + CD19 + and IL-10 + CD19 + B cells in HBV-MN patients were significantly higher than the HC, but lower than HBV-IT. Other studies 18,20 have shown that IL-10-producing cells were highly expressed in HBV-IT patients, consistent with the results of this study. HBV may induce an increase in the frequency of IL-10-producing B cells in the host, which in turn may suppress immune responses to HBV infection.…”

Section: Discussionsupporting

confidence: 93%

“…This suggests that the use of CD5 + CD1d + CD19 + alone is inadequate to define Breg cells in humans. In addition, recent publications have defined human Bregs as CD24 hi CD38 hi or CD24 hi CD27 + B cells, and shown they had a suppressive effect on other cells via IL‐10. Therefore, CD5 + CD1d + CD19 + B cells may be only one subset of Bregs in humans.…”

Section: Discussionmentioning

confidence: 99%

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A higher frequency of IL‐10‐producing B cells in Hepatitis B virus‐associated membranous nephropathy

Liu

Wang

et al. 2016

Clin Exp Pharma Physio

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The purpose of this study is to elucidate the potential role of interleukin (IL)-10(+) regulatory B cells and other B cell subsets in the development of hepatitis B virus-associated membranous nephropathy (HBV-MN). A total of 14 patients with new onset HBV-MN, 12 individuals with immune-tolerant HBV infection (HBV-IT), and 12 healthy controls (HC) were examined for the percentages of CD38(+) , CD86(+) , CD27(+) , CD95(+) and IL-10(+) B cells by flow cytometry. Serum IL-10 concentration was examined by enzyme-linked immunosorbent assay (ELISA). The percentages of CD38(+) CD19(+) , CD86(+) CD19(+) , CD38(+) CD86(+) CD19(+) , and CD95(+) CD19(+) B cells were significantly higher in HBV-MN patients than the HBV-IT and HC. The percentages of CD5(+) CD19(+) , IL-10(+) CD19(+) B cells and serum IL-10 level in HBV-MN patients were significantly higher than the HC, and lower than the HBV-IT. Percentages of CD38(+) CD19(+) , and CD86(+) CD19(+) B cells were reduced after treatment, while the percentages of CD5(+) CD1d(+) CD19(+) , CD5(+) CD1d(+) IL-10(+) CD19(+) , and IL-10(+) CD19(+) B cells were increased. The 24 h urinary protein concentration was positively correlated with the percentage of CD38(+) CD19(+) , and negatively correlated with the percentage of IL-10(+) CD19(+) B cells and serum IL-10 level. Similarly, the value of eGFR was negatively correlated with the percentage of CD38(+) CD19(+) , and positively correlated with the percentage of IL-10(+) CD19(+) B cells and serum IL-10 level. Serum IL-10 level and the percentage of IL-10(+) CD19(+) were negatively correlated with the percentages of CD38(+) CD19(+) , and CD86(+) CD19(+) B cells. These results suggest that CD86(+) CD19(+) , CD38(+) CD86(+) CD19(+) , CD95(+) CD19(+) , and especially CD38(+) CD19(+) and IL-10(+) CD19(+) cells may participate in the pathogenesis of HBV-MN.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

A higher frequency of IL‐10‐producing B cells in Hepatitis B virus‐associated membranous nephropathy

Liu

Wang

et al. 2016

Clin Exp Pharma Physio

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“…When measured before and after stimulation with CpG or HBV antigens, high numbers of CD19+CD24 hi CD38 hi Breg cells in HBV‐infected individuals have been found to correlate temporally with hepatic flares. Both IL‐10 blockade and depletion of Breg cells from total peripheral blood have been found to rescue HBV‐specific CD8+ T cell responses, indicating that the immunoregulatory function of Breg cells in HBV infection is IL‐10 mediated . Gong et al .…”

Section: Breg In Viral Infectionsmentioning

confidence: 99%

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

Wąsik

Nazimek

Bryniarski

2018

Microbiology and Immunology

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A diverse population of regulatory B (Breg) cells reportedly exhibits significant immunomodulatory effects in various models of inflammatory responses and infectious diseases caused by bacteria, viruses or parasites. Breg cells contribute to maintenance of homeostasis via IL-10 production and multiple IL-10-independent mechanisms. The current review describes various phenotypic and functional subsets of Breg cells in autoimmune and infectious diseases and discusses the impacts of experimental conditions that have been found to drive Breg cell differentiation.

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556 Role of Il-10-Producing Regulatory B Cells in the Pathogenesis of Chronic HBV Infection

Cited by 2 publications

References 0 publications

A higher frequency of IL‐10‐producing B cells in Hepatitis B virus‐associated membranous nephropathy

A higher frequency of IL‐10‐producing B cells in Hepatitis B virus‐associated membranous nephropathy

Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

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