2008
DOI: 10.1016/s0168-8278(08)60558-9
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556 Role of Il-10-Producing Regulatory B Cells in the Pathogenesis of Chronic HBV Infection

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Cited by 2 publications
(3 citation statements)
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“…In order to study IL-10-producing B cells expression in HBV-MN disease, we examined the frequency of these cells and found that the percentages of CD5 + CD19 + and IL-10 + CD19 + B cells in HBV-MN patients were significantly higher than the HC, but lower than HBV-IT. Other studies 18,20 have shown that IL-10-producing cells were highly expressed in HBV-IT patients, consistent with the results of this study. HBV may induce an increase in the frequency of IL-10-producing B cells in the host, which in turn may suppress immune responses to HBV infection.…”
Section: Discussionsupporting
confidence: 93%
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“…In order to study IL-10-producing B cells expression in HBV-MN disease, we examined the frequency of these cells and found that the percentages of CD5 + CD19 + and IL-10 + CD19 + B cells in HBV-MN patients were significantly higher than the HC, but lower than HBV-IT. Other studies 18,20 have shown that IL-10-producing cells were highly expressed in HBV-IT patients, consistent with the results of this study. HBV may induce an increase in the frequency of IL-10-producing B cells in the host, which in turn may suppress immune responses to HBV infection.…”
Section: Discussionsupporting
confidence: 93%
“…This suggests that the use of CD5 + CD1d + CD19 + alone is inadequate to define Breg cells in humans. In addition, recent publications have defined human Bregs as CD24 hi CD38 hi or CD24 hi CD27 + B cells, and shown they had a suppressive effect on other cells via IL‐10. Therefore, CD5 + CD1d + CD19 + B cells may be only one subset of Bregs in humans.…”
Section: Discussionmentioning
confidence: 99%
“…When measured before and after stimulation with CpG or HBV antigens, high numbers of CD19+CD24 hi CD38 hi Breg cells in HBV‐infected individuals have been found to correlate temporally with hepatic flares. Both IL‐10 blockade and depletion of Breg cells from total peripheral blood have been found to rescue HBV‐specific CD8+ T cell responses, indicating that the immunoregulatory function of Breg cells in HBV infection is IL‐10 mediated . Gong et al .…”
Section: Breg In Viral Infectionsmentioning
confidence: 99%