[551] Hyperhomocysteinemia in Chronic Hepatitis C: Role in Steatosis, Fibrogenesis and Response to Antiviral Treatment

Roblin, Xavier; Ducros, Véronique; Hilleret, Marie Noelle; Stürm, Nathalie; Plages, Agnès; Zarski, Jean–Pierre; Leroy, Vincent

doi:10.1016/s0168-8278(07)62149-7

Cited by 5 publications

(5 citation statements)

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“…Emerging evidences revealed that hyperhomocysteinemia contributed to a spectrum of disease development, including cardiovascular disease, diabetes, chronic kidney disease and fatty liver disease [35][36][37]. Previous reports uncovered that homocysteine concentrations were greater in many virus infections including human immunodeficiency virus, hepatitis virus and human papilloma virus [38][39][40]. However, the roles of homocysteine in coronavirus infection have not been well illustrated.…”

Section: Discussionmentioning

confidence: 99%

Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Yang

Shi

Zhang

et al. 2020

Aging

102

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Objective: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients. Results: The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The white blood cells, platelets, neutrophils and acid glycoprotein were all decreased in imaging progression patients (all p < 0.05), and monocytes were increased (p = 0.025). The parameters including homocysteine, urea, creatinine and serum cystatin C were significantly higher in imaging progression patients (all p < 0.05), while eGFR decreased (p < 0.001). Monocyte-lymphocyte ratio (MLR) was significantly higher in imaging progression patients compared to that in imaging progression-free ones (p < 0.001). Logistic models revealed that age, MLR, homocysteine and period from onset to admission were factors for predicting imaging progression on chest CT at first week from COVID-19 patients (all p < 0.05). Conclusion: Age, MLR, homocysteine and period from onset to admission could predict imaging progression on chest CT from COVID-19 patients. Methods: The primary outcome was imaging progression on chest CT. Baseline parameters were collected at the first day of admission. Imaging manifestations on chest CT were followed-up at (6±1) days.

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Section: Discussionmentioning

confidence: 99%

Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Yang

Shi

Zhang

et al. 2020

Aging

102

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“…In rodents, administering H 2 S donors reduced inflammation and oxidative stress and attenuated ventilator-induced lung injury as well as injury induced by pneumonia (159,160). In addition, the H 2 S donor, GYY4137, suppressed replication of enveloped RNA viruses like SARS-CoV-2 (161)(162)(163). Additionally, the H 2 S donor, sodium hydrosulfide, inhibits platelet activation, NET formation, DNA, and ROS levels while decreasing SOD in the hyperhomocysteinemia (HHcy) group (164).…”

Section: Potential Redox-based Therapeuticsmentioning

confidence: 99%

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

Paul

Lemle

Komaroff

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

177

179

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Although most patients recover from acute COVID-19, some experience postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC). One subgroup of PASC is a syndrome called “long COVID-19,” reminiscent of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS is a debilitating condition, often triggered by viral and bacterial infections, leading to years-long debilitating symptoms including profound fatigue, postexertional malaise, unrefreshing sleep, cognitive deficits, and orthostatic intolerance. Some are skeptical that either ME/CFS or long COVID-19 involves underlying biological abnormalities. However, in this review, we summarize the evidence that people with acute COVID-19 and with ME/CFS have biological abnormalities including redox imbalance, systemic inflammation and neuroinflammation, an impaired ability to generate adenosine triphosphate, and a general hypometabolic state. These phenomena have not yet been well studied in people with long COVID-19, and each of them has been reported in other diseases as well, particularly neurological diseases. We also examine the bidirectional relationship between redox imbalance, inflammation, energy metabolic deficits, and a hypometabolic state. We speculate as to what may be causing these abnormalities. Thus, understanding the molecular underpinnings of both PASC and ME/CFS may lead to the development of novel therapeutics.

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“…Elevated plasma Hcy concentration is now recognized as an independent risk factor for cardiovascular disease, while a limited number of studies have shown that Hcy is associated with the risk of infection [46]. Dierkes et al [47] have suggested that Hcy is not only strongly correlated with insulin resistance, but also stimulates pro-in ammatory cytokine secretion. Previous studies drew the similar conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…We suggested that the risk association between Hcy and infection in T2DM may be due to the destruction of vascular endothelial cells, increased individual susceptibility to pathogenic microorganisms and increased in ammatory responses. Since previous studies have shown that the sulfation factor-like effects of Hcy are directly toxic to endothelial cells [51] and damage endothelial cell-dependent vasodilation [47]. Destruction of endothelial cells results in impaired barrier function in the rst place.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Plasma Free Amino Acids and Type 2 Diabetes Mellitus complicated with infection in Chinese Patients

Zhang

Luo

Wang

et al. 2023

Preprint

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Background Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and the risk of T2DM complicated with infection in Chinese patients. Methods A cross-sectional study was conducted from May 2015 to August 2016.We retrieved the medical records of 1032 inpatients with T2DM from Liaoning Medical University First Affiliated Hospital and we used mass spectrometry to quantify 23 PFAAs. Infectious contained 15 individual categories that could be retrieved from the database. Principal component analysis was used to extract factors of PFAAs. Multi-variable binary logistic regression was used to obtain odds ratios (OR) and their 95% confidence intervals (CI). Results Among 1032 inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, factor 4 was positively correlated with increased risk of T2DM complicated with infection in T2DM (OR: 1.26, 95%CI: 1.05–1.52). Individual Hcy in factor 5 was positively associated with T2DM complicated with infection (OR: 1.32, 95%CI: 1.07–1.64). Furthermore, factor 4 (OR: 1.45, 95%CI: 1.12–1.88), Orn (OR: 1.01, 95%CI: 1.00-1.02) and Hcy (OR: 1.57, 95%CI: 1.14–2.15) were positively associated with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.69, 95%CI: 0.49–0.99) was negatively associated with bacterial infection. Conclusions Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were positively associated with T2DM complicated with infection in China. Orn and Hcy were positively associated with bacterial infection in T2DM patients in China.

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[551] Hyperhomocysteinemia in Chronic Hepatitis C: Role in Steatosis, Fibrogenesis and Response to Antiviral Treatment

Cited by 5 publications

References 0 publications

Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome

The Association Between Plasma Free Amino Acids and Type 2 Diabetes Mellitus complicated with infection in Chinese Patients

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