545 Precision medicine in psoriasis: machine learning and proteomics join forces to develop a blood-based test to predict response to tofacitinib or Etanercept in psoriasis patients
Abstract:We previously showed that delphinidin, a dietary small molecule, possesses prodifferentiation and anti-proliferative properties with unknown mechanism, and recently observed deregulated PI3K/Akt/mTOR signaling in human psoriasis and imiquimod (IMQ)induced murine psoriasis-like skin lesions. Using KINOMEscan, a competitive kinase binding assay platform and subsequent K d determinations we observed that from a panel of 104 kinases screened delphinidin bound to several lipid (PIK3CG, PIK3C2B, and PIK3CA) and seri… Show more
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