539 the Comparison of the Three Steps Leader and Epidural Analgesia in the Treatment the Patients With Severe Cancer Pain

Lisnyy, I.I.; Shlapak, I.P.; Bondar, M.V.; Radchuk, I.P.

doi:10.1016/s1090-3801(06)60542-9

Cited by 1 publication

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“…will conduct an independent review of the included studies by using Cochrane's tools. Since the included trials in this study complied Miaoguo Cai [14] 2020 1 50 1 + 6 50 2 wk ④ Run Chen [15] 2021 1 50 1 + 7 50 4 wk ⑤ Xuezhang Chen [16] 2020 1 49 1 + 5 49 10 d ④ Yan Chen [17] 2020 1 42 1 + 5 42 1 wk ① Yuwen Chen [18] 2017 1 30 1 + 7 30 1 wk ① Yi Deng [19] 2015 1 42 1 + 2 42 4 wk ③、⑤ Rui Gao [20] 2018 1 50 1 + 5 50 10 d ⑤ Xingcai Guo [9] 2022 1 35 1 + 2 35 Unclear ⑤ Yun He [10] 2022 [22] 2019 1 40 1 + 2 40 2 wk ②、④、⑦ Bin Jiang [20] 2020 [24] 2021 1 20 1 + 2 20 20 d ⑤ Dehui Li [25] 2017 1 30 1 + 2 30 1 wk ① Yingdong Li [11] 2022 1 75 1 + 2 75 2 wk ②、⑤ Jietao Lin [26] 2011 1 29 1 + 8 31 1 wk ④ Xinping Liu [27] 2011 1 34 1 + 5 34 4 wk ③ Jiheng Ma [28] 2018 1 33 1 + 5 54 4 wk ④ Jie Peng [29] 2012 1 24 1 + 3 23 1 wk ⑥ Daiping Qiao [30] 2008 1 30 1 + 2 33 1 wk ① Fumin Shi [31] 2021 1 41 1 + 2 41 1 wk ① Ruirui Sun [32] 2017 1 30 1 + 2 30 2 wk ②、⑤ Can Wang [33] 2019 1 40 1 + 3 40 2 wk ④ Daojun Wang [34] 2019 1 35 1 + 2 35 2 wk ②、④ Jing Wang [35] 2015 1 30 1 + 7 30 Unclear ⑤ Qingquan Wang [36] 2016 1 60 1 + 7 60 1 wk ⑤ Jinchai Xu [37] 2018 1 32 1 + 5 32 Unclear ⑤ Na Xue [12] 2022 1 57 1 + 2 57 2 wk ②、④ Jingtao Yan [38] 2017 1 50 1 + 5 50 2 wk ②、④ Liya Yang [42] 2019 1 34 1 + 6 34 1 wk ① Yimei Yu [43] 2021 1 22 1 + 2 22 1 wk ④ Yajing Zhang [44] 2014 1 18 1 + 5 27 5 d ⑥、⑦ Kai Zheng [45] 2015 1 14 1 + 2 15 2 wk ② Minyu Zhong [46] 2012 1 50 1 + 7 50 1 wk ① Deqi Zhou [47] 2016 1 33 1 + 6 32 2 wk ② Qunqin Zhou [48] 2022 1 42 1 + 2 42 2 wk ② Li Feng…”

Section: Data Extraction and Quality Assessmentmentioning

confidence: 99%

External treatment of traditional Chinese medicine for cancer pain: A systematic review and network meta-analysis

Jin,

Liang,

Zhang

et al. 2024

Medicine

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Background: Cancer pain is one of the most intolerable and frightening symptoms of cancer patients. However, the clinical effect of the three-step analgesic ladder method (TSAL) is not satisfactory. The combination of external treatment of traditional Chinese medicine (TCM) can improve the clinical effect. Objective: This study used network meta-analysis to compare the effects of different external treatment methods of TCM combined with TSAL on cancer pain. Methods: Databases searched by our team included Google Scholar, Web of Science, Scopus, Embase, PubMed, and Cochrane Library. Randomized controlled trials related to the external treatment of TCM combined with TSAL for cancer pain were screened from the establishment of the database till now. The above literature extracted clinical efficacy, NRS score, KPS score, analgesic onset time, and duration as the main results after the screening. The 95% confidence interval (95% CI) of OR value and SMD value was used as the effect index to compare the difference in efficacy of different interventions, and the ranking was conducted. STATA 17.0 software was used for the statistical analysis of the above data. Results: A total of 78 studies were included, including 8 interventions and 5742 participants. Based on ranking probability, the clinical effective rate of manual acupuncture combined with TSAL was the best when the intervention time was set at 4 weeks [OR = 5.42, 95% CI (1.99,14.81)], and the improvement effect on KPS score was also the best [SMD = 0.97, 95% CI (0.61, 1.33)]. Acupoint external application was the best intervention in reducing NRS score [SMD = −1.14, 95% CI (−1.90, −0.93)]. Acupoint moxibustion combined with TSAL was considered to be the most effective intervention to prolong the duration of analgesia [SMD = 1.69, 95% CI (0.84, 2.54)] and shortening the onset time of analgesia [SMD = −3.00, 95% CI (−4.54, −1.47)]. Conclusions: TSAL combined with manual acupuncture is the best in terms of clinical efficacy and improvement of patients’ functional activity status. With the extension of treatment time, the intervention of this kind of treatment on the clinical effect is more pronounced. Acupoint external application also has a unique advantage in reducing the pain level of patients. From the point of view of analgesic duration and duration of analgesia, combined acupoint moxibustion has the best effect.

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