This lecture is an introduction to cosmological tests with clusters of galaxies. Here I do not intend to provide a complete review of the subject, but rather to describe the basic procedures to set up the fitting machinery to constrain cosmological parameters from clusters, and to show how to handle data with a critical insight. I will focus mainly on the properties of X-ray clusters of galaxies, showing their success as cosmological tools, to end up discussing the complex thermodynamics of the diffuse intracluster medium and its impact on the cosmological tests.