528: The relation between duration of ruptured membranes and perinatal outcome in patients with midtrimester preterm prelabor rupture of membranes

Teeffelen, S.V.; Heijden, J. Van Der; Ham, David van der; Schaaf, Jelle M.; Ravelli, Anita C.J.; Pajkrt, Eva; Willekes, Christine; Nijhuis, Jan G.; Mol, Ben Willem J.

doi:10.1016/j.ajog.2011.10.546

Cited by 1 publication

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“…However, the risk for sepsis increases in neonates born to mothers with chorioamnionitis. Sepsis rates of preterm infants born after pPROM vary from 2.5% to 36.1% [2,4,[6][7][8][9]. The definition of early-onset sepsis after pPROM varies from blood culture-proven sepsis [4,6,9] to culture-proven sepsis in blood and cerebrospinal fluid [7,10], and culture-proven sepsis in any fluid [2,11] to clinical presentation consistent with sepsis without positive culture proof [2,9].…”

Section: Introductionmentioning

confidence: 99%

Clinical Early-Onset Sepsis Is Equally Valid to Culture-Proven Sepsis in Predicting Outcome in Infants after Preterm Rupture of Membranes

Grill

Olischar

Weber

et al. 2021

JCM

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Background: Culture-proven sepsis is the gold standard in early-onset neonatal sepsis diagnosis. Infants born ≤29 weeks gestation after preterm rupture of membranes in the years 2009–2015 were included in a retrospective cohort study performed at a level III fetal-maternal unit. The study aimed to compare culture-proven sepsis, clinical sepsis and positive laboratory biomarkers ≤72 h as predictors of mortality before discharge and the combined outcome of mortality or severe short-term morbidity (severe cerebral morbidity, bronchopulmonary dysplasia and retinopathy). Results: Of the 354 patients included, culture-proven sepsis, clinical sepsis and laboratory biomarkers were positive in 2.3%, 8.5% and 9.6%, respectively. The mortality rate was 37.5% for patients with culture-proven sepsis (3/8), 33.3% for patients with clinical sepsis (10/30) and 8.8% for patients with positive laboratory biomarkers (3/34), respectively. Mortality or severe morbidity occurred in 75.0% of patients with culture-proven sepsis (6/8), 80.0% of patients with clinical sepsis (24/30) and 44.1% of patients with positive laboratory biomarkers (15/34), respectively. Conclusion: In preterm infants after preterm rupture of membranes, clinical sepsis was almost four times more common and at least equally valuable in predicting mortality and mortality or severe morbidity compared to culture-proven sepsis.

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