528 Long-Term Outcome of Helicobacter pylori-Negative Idiopathic Bleeding Ulcers: A 7-Year Prospective Cohort Study

Wong, Grace K.; Ching, Jessica; Chan, Yawen; Chan, Francis K.L.

doi:10.1016/s0016-5085(08)60352-2

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“…Non-NSAID non-H. pylori ulcers have a fivefold higher risk of recurrence compared to H. pyloripositive ulcers treated with eradication therapy [16]. In a seven-year prospective cohort study, the rate of ulcer recurrence and complication was significantly higher in H. pylori-negative patients compared to those who were H. pylori-positive [32]. In the absence of established treatment protocols, long-term maintenance therapy with PPIs is often continued indefinitely, especially in elderly patients with multiple comorbidities.…”

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confidence: 99%