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Junco, Susana; Casimiro, Teresa; Ribeiro, Nuno; Cabral-Marques, Helena

doi:10.1023/a:1023022008337

Cited by 48 publications

(7 citation statements)

References 3 publications

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“…Naproxen -b-CD inclusion complexes were studied by Junco et al, [51]. More recently, the functionalized b-CD based potentiometric sensor showed considerable selectivity towards NAP in the concentration range from 5.0 3 10 À5 to 1.0 3 10 À2 mol L À1 in the working pH range 6.2-8.5 [52].…”

Section: Resultsmentioning

confidence: 99%

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

et al. 2018

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Novel sensitive disposable sensors have been introduced for potentiometric determination of naproxen (NAP) based on single‐walled carbon nanotubes‐polyvinyl chloride (SWNTs‐PVC) composite incorporated of calix[4]arene as host‐guest molecular recognition element. The electrode matrix composition was optimized on the basis of the nature and content of the sensing element, cationic sites, plasticizer and nanomaterial. Remarkable selectivity and sensitivity towards NAP was achieved in the concentration range from 10−8 to 10−2 mol L−1 with anionic Nernstian compliance −61.0±0.0 mV decade−1. Modification with calixarene and carbon nanotubes improved the sensors performance through formation of NAP‐calixarene inclusion complex and promotion of the electron‐transfer processes which enhance the potential stability, response time, and shelf lifetime of the sensor. The proposed sensors were successfully applied for the potentiometric assay of NAP in dosage formulation and biological fluids under batch and flow injection analysis (FIA) conditions with average recoveries agreeable with the reported official methods.

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Section: Resultsmentioning

confidence: 99%

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

et al. 2018

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“…However, from the exam of some literature works involving the ketoprofen/βCD system [39,42] it can be concluded that using water as a cosolvent leads to results similar to those obtained when water is added to the physi-cal mixtures as an auxiliary agent [32]. Other experiments reported the use of different cosolvents, and the use of ethanol was particularly successful [17,18,37]. Grandelli and coworkers [37], who investigated the piroxicam/βCD system, explained that the addition of a cosolvent may favor the melting point depression of the drug.…”

Section: Scco 2 -Insoluble Cyclodextrins: Role Of the Auxiliary Agent...mentioning

confidence: 91%

“…As a conclusion of this section, it must be pointed out that many works compared the scCO 2 -obtained formulations with those prepared with conventional techniques [18,27,30,31,33,36,40,41,45,46,49,53,54,57,59,61,62,64,67,68,85,88,89,98], such as coprecipitation, heat-sealing, co-grinding, freeze drying, kneading, etc. The comparison was performed either in terms of sample characterization or in terms of drug release profiles or both, depending on the specific research report.…”

Section: A Brief Overview Of the Techniques Employed To Characterize ...mentioning

confidence: 99%

“…Furthermore, auxiliary agents such as acids, amino acids, polymers, water, or their combinations can often be added [19,22,32,34,38,43,52,63]. Another strategy is to employ supercritical mixtures of CO 2 and a cosolvent such as ethanol or water [17,18,37,39,44]. In Sections 4.2 and 4.3 the role of the working conditions (temperature and pressure) as well as that of auxiliary agents and cosolvents on the complexation efficiency of scCO 2 -insoluble cyclodextrins is discussed.…”

Section: Complexation Through Supercritical Solvent Impregnationmentioning

confidence: 99%

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Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins

Banchero

2021

Pharmaceuticals

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Cyclodextrins are widely used in pharmaceutics to enhance the bioavailability of many drugs. Conventional drug/cyclodextrin complexation techniques suffer from many drawbacks, such as a high residual content of toxic solvents in the formulations, the degradation of heat labile drugs and the difficulty in controlling the size and morphology of the product particles. These can be overcome by supercritical fluid technology thanks to the outstanding properties of supercritical CO2 (scCO2) such as its mild critical point, its tunable solvent power, and the absence of solvent residue after depressurization. In this work the use of scCO2 as an unconventional medium to achieve the complexation with native and substituted cyclodextrins of over 50 drugs, which belong to different classes, are reviewed. This can be achieved with different approaches such as the “supercritical solvent impregnation” and “particle-formation” techniques. The different techniques are discussed to point out how they affect the complexation mechanism and efficiency, the physical state of the drug as well as the particle size distribution and morphology, which finally condition the release kinetics and drug bioavailability. When applicable, the results obtained for the same drug with various cyclodextrins, or different complexation techniques are compared with those obtained with conventional approaches.

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“…Examples of successful applications of the use of cyclodextrins include encapsulation substrates such as drugs, food products, and natural pesticides [ 2 , 3 , 4 , 5 , 6 , 7 ]. The synthesis of β-cyclodextrin inclusion complexes can be accomplished through methods such as co-precipitation [ 8 , 9 ], kneading [ 10 , 11 ], ultrasonication [ 12 , 13 ], freeze-drying [ 14 ], spray-drying [ 15 ], and the use of supercritical fluids [ 16 ]. Synthetic methods currently available are simple, require no (or limited amount of) organic solvents and no additional purification or cleanup steps, and use non-toxic materials, which makes the preparation of β-cyclodextrin inclusion complexes a desired and environmentally friendly process that falls into the green-synthesis approach [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Novel β-Cyclodextrin and Catnip Essential Oil Inclusion Complex and Its Tick Repellent Properties

2021

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Cyclodextrin inclusion complexes have been successfully used to encapsulate essential oils, improving their physicochemical properties and pharmacological effects. Besides being well-known for its effects on cats and other felines, catnip (Nepeta cataria) essential oil demonstrates repellency against blood-feeding pests such as mosquitoes. This study evaluates the tick repellency of catnip oil alone and encapsulated in β-cyclodextrin, prepared using the co-precipitation method at a 1:1 molar ratio. The physicochemical properties of this inclusion complex were characterized using GC-FID for encapsulation efficiency and yield and SPME/GC-MS for volatile emission. Qualitative assessment of complex formation was done by UV-Vis, FT-IR, 1H NMR, and SEM analyses. Catnip oil at 5% (v/v) demonstrated significant tick repellency over time, being comparable to DEET as used in commercial products. The prepared [catnip: β-CD] inclusion complex exerted significant tick repellency at lower concentration of the essential oil (equivalent of 1% v/v). The inclusion complex showed that the release of the active ingredient was consistent after 6 h, which could improve the effective repellent duration. These results demonstrated the effective tick repellent activity of catnip essential oil and the successful synthesis of the inclusion complex, suggesting that β-CDs are promising carriers to improve catnip oil properties and to expand its use in repellent formulations for tick management.

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Cited by 48 publications

References 3 publications

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

Novel Calixarene/Carbon Nanotubes Based Screen Printed Sensors for Flow Injection Potentiometric Determination of Naproxen

Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins

Novel β-Cyclodextrin and Catnip Essential Oil Inclusion Complex and Its Tick Repellent Properties

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