Untitled

Кузнецова, О. А.; Filyakova, V. I.; Pashkevich, K. I.; Уломский, Е. Н.; Плеханов, П. В.; Rusinov, Gennady L.; Кодесс, М. И.; Русинов, В. Л.

doi:10.1023/a:1024777828344

Cited by 21 publications

(12 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, certain lithium 1,3-diketonates have proven to be better synthons than the corresponding diketones 15 . Previous mechanistic conclusions have been confirmed by isolating stable intermediate 5-amino-1, 2, 4-triazole derivatives such as enamine (6) (Scheme 2) on reacting 5-amino-1, 2, 4-triazoles with 3-ketovinyl ethers 16 , 3-ketoenamines 17 , 3-ketoaldehydes 18 , enamine-2-carboxylic esters 19 or ethoxymethylene malonates 20 . …”

Section: Introductionmentioning

confidence: 74%

Microwave Assisted Synthesis and Biological Evaluation of 1, 2, 4-Triazolo[1, 5-a]pyrimidines

2017

Chem Sci Trans

View full text Add to dashboard Cite

Abstract:A microwave assisted synthesis of three new series of of 1, 2, 4-triazolo[1, 5-a]pyrimidines (PK-101 to PK-110) has been synthesized by the mixture of 5-(methylthio)-2H-1,2,4-triazol-3-amine (0.01 mol), 4,4,4-trifluoro-1-(4-methoxyphenyl)butane-1,3-dione (0.01 mol) and an appropriate aromatic aldehyde (0.01 mol) in ethanol (5 mL) was irradiated under microwave conditions at 120 °C for 10-15 min. The structures of all the newly synthesized compounds are elucidated by FT-IR, mass spectra, 1 H NMR and elemental analysis. The newly synthesized compounds are subjected to various biological activities viz., antimicrobial, antimycobacterial, anticancer and antiviral.

show abstract

Section: Introductionmentioning

confidence: 74%

Microwave Assisted Synthesis and Biological Evaluation of 1, 2, 4-Triazolo[1, 5-a]pyrimidines

2017

Chem Sci Trans

View full text Add to dashboard Cite

show abstract

“…In the succeeding step, the cyclocondensation reaction of compounds 2 with heterocyclic amines (3, 4, and 7) in an oil bath at 160Ϫ165°C gave the novel compounds 2, cleophilic than the N(4) atom in 1,2,4-triazole ring [31,32], the cyclocondensation reaction proceeds through 3-amino-2H-1,2,4-triazole (5) and 3,5-diamino-2H-1,2,4-triazole (6) structures and, thus, compounds 10 and 12 are more likely to form. Therefore, the products of the above-mentioned reactions are taken as compound 10 and 12 throughout this article, but not compounds 11 and 13.…”

Section: Resultsmentioning

confidence: 99%

Convenient Synthesis of Fused Heterocyclic 1,3,5‐Triazines from Some N‐Acyl Imidates and Heterocyclic Amines as Anticancer and Antioxidant Agents

Bekircan

Küxük

Kahveci

et al. 2005

Archiv der Pharmazie

View full text Add to dashboard Cite

N-Acyl imidates (2), reacting with 5-amino pyrazole (3), 2-aminobenzimidazole (4), 3-amino-1,2,4-triazole (5), 3,5-diamino-1,2,4-triazole (6), and 5-aminotetrazole (7) give pyrazolo[1,5-a][1,3,5]triazine (8), benzo[4,5]imidazo[1,2-a][1,3,5]triazine (9), [1,2,4]triazolo [2,3-a][1,3,5]triazine (10), [1,2,4]tri azolo[2,3-a][1,3,5]triazin-5-ylamine (12), and tetrazolo-[1,5-a][1,3,5]triazine (14) derivatives, respectively. The synthesized compounds were characterized on the basis of IR, (1)H-NMR, (13)C-NMR, and mass spectral data and elemental analyses results. Five of the newly synthesized compounds, 8a, 9a, 10a, 12a, and 14a, were selected by National Cancer Institute and screened for their anticancer activity against three cancer cell lines MCF7, NCI-H460, and SF-268, where 12a exhibited moderate anti-proliferation potential. 12a was, thus, further tested for anticancer activity against 60 human cancer cell lines and showed moderate growth inhibition potency. 12a showed a high growth inhibitory activity against A498 renal cancer cell line. All of the newly synthesized compounds 8-10, 12 and 14 were tested for their antioxidant capacity where they exhibited very high activity, even higher than the widely used reference antioxidants butylated hydroxytoluene and 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox). Compound 12a also showed the highest antioxidant activity.

show abstract

“…In addition, they have been found in DNA-interactive drugs 11 and as useful building blocks in the synthesis of herbicidal For the preparation of complex molecules, large efforts have been directed towards the synthetic manipulation of triazolopyrimidines. As a result, a number of reports have appeared which usually require drastic conditions, long reaction times and complex synthetic pathways and often react in organic solvents [12][13][14][15][16] , which are least desirable commercially. Thus, developing efficient, selective and ecofriendly synthetic methods for applications in complex organic preparations is the ultimate goal of several research group including ours.…”

Section: Introductionmentioning

confidence: 99%

Mild and ecofriendly tandem synthesis of 1,2,4-triazolo[4,3-a]pyrimidines in aqueous medium

Dandia¹,

Sarawgi²,

Arya³

et al. 2007

Arkivoc

View full text Add to dashboard Cite

A rapid, efficient, clean and environmentally benign exclusive synthesis of 1,2,4-triazolo [4,3-a]pyrimidines from the reaction of amino triazole, carbonyl compounds and alkene-nitrile derivatives has been developed in an aqueous medium in an excellent yields using microwaves or ultrasonic waves. The results are compared with conventional heating. Structural assignments are based on spectroscopic data (IR,

show abstract

Untitled

Cited by 21 publications

References 3 publications

Microwave Assisted Synthesis and Biological Evaluation of 1, 2, 4-Triazolo[1, 5-a]pyrimidines

Microwave Assisted Synthesis and Biological Evaluation of 1, 2, 4-Triazolo[1, 5-a]pyrimidines

Convenient Synthesis of Fused Heterocyclic 1,3,5‐Triazines from Some N‐Acyl Imidates and Heterocyclic Amines as Anticancer and Antioxidant Agents

Mild and ecofriendly tandem synthesis of 1,2,4-triazolo[4,3-a]pyrimidines in aqueous medium

Contact Info

Product

Resources

About