513MO Risk and mortality of testicular cancer in patients with psychiatric or neurodevelopmental disorders

Jansson, Anna-Karin; Söderling, JK; Reutfors, Johan; Thor, Anna; Sköld, Christian; Cohn‐Cedermark, Gabriella; Ståhl, Olof; Smedby, Karin E.; Pettersson, Andreas; Glimelius, Ingrid

doi:10.1016/j.annonc.2022.07.641

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“…Knowledge of and findings relating to similar etiological factors-such as chromosomal abnormalities-are also of interest because there is an increased risk for men who have a father and a brother with testicular cancer. The novel findings of a slightly increased risk for patients with neurodevelopmental disorders to get seminoma [36] could potentially also be investigated with a closer genetic characterization. Similarities, differences, and suggested learning points are summarized in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…For women, one case report describes two patients with a clear family history of GCT in which one son developed testicular cancer and one daughter had an ovarian GCT, indicating this as an interesting area for future investigation also in women [21]. Other risk factors in males that would be interesting to investigate for their presence in females include previous GCT in the contralateral gonad (testicle or ovarium) [30], inguinal hernia [31][32][33], other urogenital malformations [31], low birth weight, short gestational age, twinning [34,35], or presence of concomitant neurodevelopmental disorders [36].…”

Section: Common Risk Factors For Testicular and Ovarian Germ Cell Tumorsmentioning

confidence: 99%

“…Among patients with seminoma and non‐seminoma clinical stage I, the 5‐year overall survival was 99.3% and 99.4%, respectively, and among patients with metastases at diagnosis, the overall 5‐year survival was 95.3% among seminoma patients and 94.1% among non‐seminoma patients [82]. Because survival data comparing ovarian and testicular GCTs by stage and age were difficult to find, we analyzed the survival in population‐based cohorts with data used in previous studies (testicular [36, 83]; ovarian GCTs [84]). In these cohorts of Swedish patients with testicular (4150 with seminomas and 3513 with non‐seminomas, 1995–2022) and ovarian (67 with dysgerminomas and 226 with non‐dysgerminomas, 1990–2018) GCTs, 10‐year overall survival in seminoma patients was 99.1%, compared with 92.8% in dysgerminoma patients (Fig.…”

Section: Survivalmentioning

confidence: 99%

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Malignant ovarian and testicular germ cell tumors: Common characteristics but different prognoses

Sköld,

Jansson,

Glimelius

2024

J Intern Med

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Both ovarian and testicular germ cell tumors (GCTs) arise from the primordial germ cell and share many similarities. Both malignancies affect mainly young patients, show remarkable responsiveness to cisplatin‐based therapy, and have an excellent prognosis, which also highlights the importance of minimizing long‐term side effects. However, certain differences can be noted: The spreading of the disease differs, and the staging system and treatment recommendations are dissimilar. Moreover, the prognosis for ovarian GCTs is significantly inferior to that for testicular cancer, as exemplified in this review comparing the survival in Swedish patients diagnosed with testicular (1995–2022) and ovarian (1990–2018) GCTs. The 5‐year overall survival in ovarian GCTs was 85.2%, versus 98.2% for testicular GCTs. How can this be explained? One reason may be the difference in knowledge, experience, and evidence because the incidence rate of testicular cancer is more than 15 times that of ovarian GCTs. Given the rarity of the disease in women and the lack of established guidelines, a comprehensive understanding of the disease and treatment decisions is challenging. The main objective of this review is to derive insights from testicular GCTs (seminoma and non‐seminoma) by reviewing etiological, tumor biological, and clinical knowledge, and to thereafter suggest actions for ovarian GCTs based on this. We hypothesize that by adopting specific treatment strategies from testicular GCTs—including de‐escalating adjuvant chemotherapy for low‐risk patients and implementing more standardized and intensive treatment protocols in cases of relapse—we can improve the prognosis and minimize long‐term side effects in ovarian GCT patients.

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Section: Discussionmentioning

confidence: 99%

Section: Common Risk Factors For Testicular and Ovarian Germ Cell Tumorsmentioning

confidence: 99%

Section: Survivalmentioning

confidence: 99%

See 1 more Smart Citation

Malignant ovarian and testicular germ cell tumors: Common characteristics but different prognoses

Sköld,

Jansson,

Glimelius

2024

J Intern Med

View full text Add to dashboard Cite

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513MO Risk and mortality of testicular cancer in patients with psychiatric or neurodevelopmental disorders

Cited by 1 publication

References 0 publications

Malignant ovarian and testicular germ cell tumors: Common characteristics but different prognoses

Malignant ovarian and testicular germ cell tumors: Common characteristics but different prognoses

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